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Wanjian Tang
Wanjian Tang
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Year
Omecamtiv mecarbil enhances the duty ratio of human β-cardiac myosin resulting in increased calcium sensitivity and slowed force development in cardiac muscle
AM Swenson, W Tang, CA Blair, CM Fetrow, WC Unrath, MJ Previs, ...
Journal of Biological Chemistry 292 (9), 3768-3778, 2017
932017
Modulating beta-cardiac myosin function at the molecular and tissue levels
W Tang, CA Blair, SD Walton, A Málnási-Csizmadia, KS Campbell, ...
Frontiers in physiology 7, 228510, 2017
272017
FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V
LK Gunther, JA Rohde, W Tang, JA Cirilo, CP Marang, BD Scott, ...
Journal of Biological Chemistry 295 (51), 17383-17397, 2020
232020
Converter domain mutations in myosin alter structural kinetics and motor function
LK Gunther, JA Rohde, W Tang, SD Walton, WC Unrath, DV Trivedi, ...
Journal of Biological Chemistry 294 (5), 1554-1567, 2019
222019
Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil
W Tang, WC Unrath, R Desetty, CM Yengo
Journal of Biological Chemistry 294 (46), 17314-17325, 2019
202019
Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin
W Tang, J Ge, WC Unrath, R Desetty, CM Yengo
Biophysical journal 120 (11), 2222-2236, 2021
142021
Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions
AM Touma, W Tang, DV Rasicci, D Vang, A Rai, SB Previs, DM Warshaw, ...
Biophysical journal 121 (12), 2449-2460, 2022
72022
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
S Gerhardy, M Ultsch, W Tang, E Green, JK Holden, W Li, A Estevez, ...
Nature Communications 13 (1), 5222, 2022
42022
FRET and Optical Trapping Measurements Reveal Relationship between Phosphate Release and the Power Stroke in Myosin V
EP Debold, LK Gunther, M Unger, B Scott, W Tang, CM Yengo
Biophysical Journal 118 (3), 177a, 2020
12020
Inter‐filament co‐operativity is crucial for regulating muscle contraction
W Tang, CM Yengo
The Journal of Physiology 596 (1), 17, 2018
12018
Cardiomyopathy Mutations in the Converter Domain of Human Beta-Cardiac Myosin Impairs Mechanochemistry in the Presence and Absence of Load
W Tang, SD Walton, WC Unrath, CM Yengo
Biophysical Journal 112 (3), 120a, 2017
12017
Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay
AM Touma, W Tang, DV Rasicci, D Vang, A Rai, SB Previs, DM Warshaw, ...
bioRxiv, 2022.03. 11.483820, 2022
2022
Dissecting cardiac myosin-binding protein C interactions on a synthetic β-cardiac myosin DNA nanotube thick filament
AM Touma, D Vang, W Tang, D Rasicci, A Rai, SB Previs, DM Warshaw, ...
Biophysical Journal 121 (3), 257a, 2022
2022
Cardiomyopathy Mutations Impact the Power Stroke of Human Cardiac Myosin
W Tang, J Ge, WC Unrath, R Desetty, CM Yengo
bioRxiv, 2020.12. 08.416511, 2020
2020
Impact of Regulatory Light Chain Mutation (K104E) on the Atpase and Motor Properties of Human Cardiac Myosin
D Rasicci, O Kirkland, W Tang, R Desetty, CM Yengo
Biophysical Journal 118 (3), 425a, 2020
2020
FRET Measurements of the Power Stroke in Human Cardiac Myosin
W Tang, J Ge, R Dessety, CM Yengo
Biophysical Journal 118 (3), 7a, 2020
2020
The S217A Mutant Slows the Power Stroke and Phosphate Release in Myosin V
LK Gunther, W Tang, CM Yengo
Biophysical Journal 116 (3), 260a, 2019
2019
Impact of Human Beta-Cardiac Myosin Mutation Implicated in Both Hypertrophic and Dilated Cardiomyopathy
W Tang, LK Gunther, J Cooper, R Desetty, CM Yengo
Biophysical Journal 116 (3), 263a-264a, 2019
2019
Mutations in the Converter Domain of Myosin V Demonstrate Coupling Between Lever Arm Swing and Phosphate Release
LK Gunther, SD Walton, W Tang, WC Unrath, D Trivedi, CM Yengo
Biophysical Journal 114 (3), 321a, 2018
2018
Impact of Dilated Cardiomyopathy Mutation and Small Molecule Regulator on Human Beta-Cardiac Myosin
W Tang, WC Unrath, R Desetty, CM Yengo
Biophysical Journal 114 (3), 496a, 2018
2018
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Articles 1–20