Olivia Merkel
Olivia Merkel
Professor of Drug Delivery, Ludwig-Maximilians-Universität München
Verified email at lmu.de - Homepage
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Cited by
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly (ethylene imine)-graft-poly (ethylene glycol) block copolymer/SiRNA …
S Mao, M Neu, O Germershaus, O Merkel, J Sitterberg, U Bakowsky, ...
Bioconjugate chemistry 17 (5), 1209-1218, 2006
Stability of siRNA polyplexes from poly (ethylenimine) and poly (ethylenimine)-g-poly (ethylene glycol) under in vivo conditions: effects on pharmacokinetics and …
OM Merkel, D Librizzi, A Pfestroff, T Schurrat, K Buyens, NN Sanders, ...
Journal of controlled release: official journal of the Controlled Release …, 2009
Controlled pulmonary drug and gene delivery using polymeric nano-carriers
M Beck-Broichsitter, OM Merkel, T Kissel
Journal of controlled release 161 (2), 214-224, 2012
Nonviral siRNA delivery to the lung: Investigation of PEG− PEI polyplexes and their in vivo performance
OM Merkel, A Beyerle, D Librizzi, A Pfestroff, TM Behr, B Sproat, PJ Barth, ...
Molecular pharmaceutics 6 (4), 1246-1260, 2009
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI (–PEG)/siRNA complexes
A Malek, O Merkel, L Fink, F Czubayko, T Kissel, A Aigner
Toxicology and applied pharmacology 236 (1), 97-108, 2009
Applications of polymer micelles for imaging and drug delivery
S Movassaghian, OM Merkel, VP Torchilin
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 7 (5 …, 2015
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy
J Nguyen, TWJ Steele, O Merkel, R Reul, T Kissel
Journal of controlled release 132 (3), 243-251, 2008
In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly (ethylene glycol) block copolymers
OM Merkel, R Urbanics, P Bedőcs, Z Rozsnyay, L Rosivall, M Toth, ...
Biomaterials 32 (21), 4936-4942, 2011
Nonviral pulmonary delivery of siRNA
OM Merkel, T Kissel
Accounts of chemical research 45 (7), 961-970, 2012
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity
OM Merkel, MA Mintzer, D Librizzi, O Samsonova, T Dicke, B Sproat, ...
Molecular pharmaceutics 7 (4), 969-983, 2010
siRNA delivery to the lung: what's new?
OM Merkel, I Rubinstein, T Kissel
Advanced drug delivery reviews 75, 112-128, 2014
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure
OM Merkel, D Librizzi, A Pfestroff, T Schurrat, M Béhé, T Kissel
Bioconjugate chemistry 20 (1), 174-182, 2009
Polymer-related off-target effects in non-viral siRNA delivery
OM Merkel, A Beyerle, BM Beckmann, M Zheng, RK Hartmann, T Stöger, ...
Biomaterials 32 (9), 2388-2398, 2011
Comparative in vivo study of poly (ethylene imine)/siRNA complexes for pulmonary delivery in mice
A Beyerle, A Braun, O Merkel, F Koch, T Kissel, T Stoeger
Journal of controlled release 151 (1), 51-56, 2011
Computational insights into the interactions between DNA and siRNA with “rigid” and “flexible” triazine dendrimers
GM Pavan, MA Mintzer, EE Simanek, OM Merkel, T Kissel, A Danani
Biomacromolecules 11 (3), 721-730, 2010
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity
OM Merkel, MA Mintzer, J Sitterberg, U Bakowsky, EE Simanek, T Kissel
Bioconjugate chemistry 20 (9), 1799-1806, 2009
Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly (ethylene glycol) copolymers
M Zheng, D Librizzi, A Kılıç, Y Liu, H Renz, OM Merkel, T Kissel
Biomaterials 33 (27), 6551-6558, 2012
PEGylation affects cytotoxicity and cell-compatibility of poly (ethylene imine) for lung application: structure–function relationships
A Beyerle, O Merkel, T Stoeger, T Kissel
Toxicology and applied pharmacology 242 (2), 146-154, 2010
Targeting the blind spot of polycationic nanocarrier-based siRNA delivery
M Zheng, GM Pavan, M Neeb, AK Schaper, A Danani, G Klebe, ...
ACS nano 6 (11), 9447-9454, 2012
Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI–PCL–PEG–Fol)
L Liu, M Zheng, D Librizzi, T Renette, OM Merkel, T Kissel
Molecular pharmaceutics 13 (1), 134-143, 2016
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