| Impact of a five-dimensional framework on R&D productivity at AstraZeneca P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ... Nature reviews Drug discovery 17 (3), 167-181, 2018 | 376 | 2018 |
| Malate dehydrogenase: a model for structure, evolution, and catalysis CR Goward, DJ Nicholls Protein Science 3 (10), 1883-1888, 1994 | 309 | 1994 |
| Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase ED Garcin, AS Arvai, RJ Rosenfeld, MD Kroeger, BR Crane, G Andersson, ... Nature chemical biology 4 (11), 700-707, 2008 | 250 | 2008 |
| Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes. ZB Moola, MD Scawen, T Atkinson, DJ Nicholls Biochem. J 302, 921-927, 1994 | 137 | 1994 |
| 1, 2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo AC Tinker, HG Beaton, N Boughton-Smith, TR Cook, SL Cooper, ... Journal of medicinal chemistry 46 (6), 913-916, 2003 | 122 | 2003 |
| Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist DJ Nicholls, K Wiley, I Dainty, F MacIntosh, C Phillips, A Gaw, CK Mårdh Journal of Pharmacology and Experimental Therapeutics 353 (2), 340-350, 2015 | 89 | 2015 |
| Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2 DJ Nicholls, NP Tomkinson, KE Wiley, A Brammall, L Bowers, ... Molecular pharmacology 74 (5), 1193-1202, 2008 | 88 | 2008 |
| Evaluation of a series of bicyclic CXCR2 antagonists I Walters, C Austin, R Austin, R Bonnert, P Cage, M Christie, M Ebden, ... Bioorganic & medicinal chemistry letters 18 (2), 798-803, 2008 | 78 | 2008 |
| The importance of arginine 102 for the substrate specificity of Escherichia coli malate dehydrogenase DJ Nicholls, J Miller, MD Scawen, AR Clarke, JJ Holbrook, T Atkinson, ... Biochemical and biophysical research communications 189 (2), 1057-1062, 1992 | 56 | 1992 |
| Formoterol and salmeterol induce a similar degree of β2‐adrenoceptor tolerance in human small airways but via different mechanisms PR Cooper, RC Kurten, J Zhang, DJ Nicholls, IA Dainty, RA Panettieri British journal of pharmacology 163 (3), 521-532, 2011 | 54 | 2011 |
| 2-Aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution S Connolly, A Aberg, A Arvai, HG Beaton, DR Cheshire, AR Cook, ... Journal of medicinal chemistry 47 (12), 3320-3323, 2004 | 53 | 2004 |
| 3, 4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency H Beaton, P Hamley, DJ Nicholls, AC Tinker, AV Wallace Bioorganic & medicinal chemistry letters 11 (8), 1023-1026, 2001 | 47 | 2001 |
| A comparative evaluation of short-term streamflow forecasting using time series analysis and rainfall-runoff models in eWater source D Dutta, WD Welsh, J Vaze, SSH Kim, D Nicholls Water resources management 26 (15), 4397-4415, 2012 | 43 | 2012 |
| Cloning and overexpression of Lactobacillus helveticusd‐lactate dehydrogenase gene in Escherichia coli S KOCHHAR, H HOTTINGER, N CHUARD, PG TAYLOR, T ATKINSON, ... European Journal of Biochemistry 208 (3), 799-805, 1992 | 40 | 1992 |
| Tetrameric malate dehydrogenase from a thermophilic Bacillus: cloning, sequence and overexpression of the gene encoding the enzyme and isolation and characterization of the … S Wynne, D Nicholls, M Scawen, T Sundaram Biochem. J 317, 235-245, 1996 | 38 | 1996 |
| Thienopyridines: Nitric oxide synthase inhibitors with potent in vivo activity H Beaton, N Boughton-Smith, P Hamley, A Ghelani, DJ Nicholls, ... Bioorganic & medicinal chemistry letters 11 (8), 1027-1030, 2001 | 33 | 2001 |
| Agonist‐specific patterns of β2‐adrenoceptor responses in human airway cells during prolonged exposure C Düringer, G Grundström, E Gürcan, IA Dainty, M Lawson, SH Korn, ... British journal of pharmacology 158 (1), 169-179, 2009 | 30 | 2009 |
| Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action MJ Stocks, L Alcaraz, A Bailey, R Bonnert, E Cadogan, J Christie, J Dixon, ... ACS medicinal chemistry letters 5 (4), 416-421, 2014 | 29 | 2014 |
| Design driven HtL: The discovery and synthesis of new high efficacy β 2-agonists MJ Stocks, L Alcaraz, A Bailey, R Bonnert, E Cadogan, J Christie, ... Bioorganic & medicinal chemistry letters 21 (13), 4027-4031, 2011 | 29 | 2011 |
| The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) DR Cheshire, A Åberg, GMK Andersson, G Andrews, HG Beaton, ... Bioorganic & medicinal chemistry letters 21 (8), 2468-2471, 2011 | 29 | 2011 |
