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Edward Pokrishevsky
Edward Pokrishevsky
Verified email at sfu.ca
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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms
LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ...
Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014
4572014
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
LI Grad, WC Guest, A Yanai, E Pokrishevsky, MA O'Neill, E Gibbs, ...
Proceedings of the National Academy of Sciences 108 (39), 16398-16403, 2011
3052011
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis
E Pokrishevsky, LI Grad, M Yousefi, J Wang, IR Mackenzie, NR Cashman
PloS one 7 (4), e35050, 2012
2202012
TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion
E Pokrishevsky, LI Grad, NR Cashman
Scientific reports 6 (1), 22155, 2016
872016
Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit
WC Guest, JM Silverman, E Pokrishevsky, MA O'Neill, LI Grad, ...
Journal of Toxicology and Environmental Health, Part A 74 (22-24), 1433-1459, 2011
762011
Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding
LI Grad, E Pokrishevsky, JM Silverman, NR Cashman
Prion 8 (5), 331-335, 2014
702014
Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells
E Pokrishevsky, L McAlary, NE Farrawell, B Zhao, M Sher, JJ Yerbury, ...
Scientific Reports 8 (1), 15590, 2018
452018
Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells
E Pokrishevsky, RH Hong, IR Mackenzie, NR Cashman
PloS one 12 (9), e0184384, 2017
362017
Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics
MG DuVal, VK Hinge, N Snyder, R Kanyo, J Bratvold, E Pokrishevsky, ...
Neurobiology of disease 124, 297-310, 2019
312019
Intercellular prion-like conversion and transmission of Cu/Zn superoxide dismutase (SOD1) in cell culture
LI Grad, E Pokrishevsky, NR Cashman
Prions: Methods and Protocols, 357-367, 2017
82017
Misfolded wild-type SOD1 induced by pathological FUS or TDP-43 transmits intercellularly and is propagation-competent
E Pokrishevsky, L Grad, N Cashman
Prion 9, S7-S8, 2015
22015
Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1
E Pokrishevsky, MG DuVal, L McAlary, S Louadi, S Pozzi, A Roman, ...
bioRxiv, 2020.07. 27.224188, 2020
12020
P4‐163: THE PATHOLOGICAL INTERACTOME OF TDP‐43 INCLUDES HUMAN WILDTYPE SOD1
E Pokrishevsky, M DuVal, L McAlary, B Zhao, E Gibbs, S Louadi, J Kaplan, ...
Alzheimer's & Dementia 15, P1336-P1337, 2019
2019
TDP-43 induces SOD1 aggregation and toxicity via tryptophan interactions that present a novel drug target
MG DuVal, E Pokrishevsky, VK Hinge, J Bratvold, R Kanyo, N Snyder, ...
PRION 13, 110-111, 2019
2019
Induction of Cu/Zn Superoxide Dismutase (SOD1) Aggregation in Living Cells
E Pokrishevsky, J Nan, NR Cashman
Protein Misfolding Diseases: Methods and Protocols, 213-224, 2019
2019
Induction of wild-type SOD1 misfolding, aggregation and its cell-to-cell propagation
E Pokrishevsky
University of British Columbia, 2017
2017
Aberrant localization of fused in sarcoma (FUS) and TAR DNA binding protein (TDP)-43 triggers misfolding of human Cu/Zn superoxide dismutase (SOD1)
E Pokrishevsky
University of British Columbia, 2011
2011
Prion-Like Propagation of SOD1 Misfolding In Vitro
NR Cashman, LI Grad, A Yanai, W Guest, MA O'Neill, E Pokrishevsky, ...
NEUROLOGY 74 (9), A503-A503, 2010
2010
PRION-LIKE MECHANISMS IN AMYOTROPHIC LATERAL SCLEROSIS
LI Grad, E Pokrishevsky, NR Cashman
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Articles 1–19