Leslie I Grad
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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms
LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ...
Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
LI Grad, WC Guest, A Yanai, E Pokrishevsky, MA O'Neill, E Gibbs, ...
Proceedings of the National Academy of Sciences 108 (39), 16398-16403, 2011
Clinical spectrum of amyotrophic lateral sclerosis (ALS)
LI Grad, GA Rouleau, J Ravits, NR Cashman
Cold Spring Harbor perspectives in medicine 7 (8), a024117, 2017
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis
E Pokrishevsky, LI Grad, M Yousefi, J Wang, IR Mackenzie, NR Cashman
PloS one 7 (4), e35050, 2012
Mitochondrial respiratory chain deficiency inCaenorhabditis elegans results in developmental arrest and increased life span
WY Tsang, LC Sayles, LI Grad, DB Pilgrim, BD Lemire
Journal of Biological Chemistry 276 (34), 32240-32246, 2001
Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis
LI Grad, BD Lemire
Human molecular genetics 13 (3), 303-314, 2004
Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites
BDM Bean, SK Dziurdzik, KL Kolehmainen, CMS Fowler, WK Kwong, ...
Journal of Cell Biology 217 (10), 3593-3607, 2018
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1
JM Silverman, D Christy, CC Shyu, KM Moon, S Fernando, Z Gidden, ...
Journal of Biological Chemistry 294 (10), 3744-3759, 2019
Disease mechanisms in ALS: misfolded SOD1 transferred through exosome-dependent and exosome-independent pathways
JM Silverman, SM Fernando, LI Grad, AF Hill, BJ Turner, JJ Yerbury, ...
Cellular and molecular neurobiology 36, 377-381, 2016
From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis
LI Grad, SM Fernando, NR Cashman
Neurobiology of disease 77, 257-265, 2015
TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion
E Pokrishevsky, LI Grad, NR Cashman
Scientific reports 6 (1), 22155, 2016
Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis
LI Grad, NR Cashman
Prion 8 (1), 33-41, 2014
Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit
WC Guest, JM Silverman, E Pokrishevsky, MA O'Neill, LI Grad, ...
Journal of Toxicology and Environmental Health, Part A 74 (22-24), 1433-1459, 2011
Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding
LI Grad, E Pokrishevsky, JM Silverman, NR Cashman
Prion 8 (5), 331-335, 2014
Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants
LI Grad, BD Lemire
Biochimica Et Biophysica Acta (BBA)-Bioenergetics 1757 (2), 115-122, 2006
Isolation and Functional Analysis of Mitochondria From the Nematode Caenorhabditis elegans
LI Grad, LC Sayles, BD Lemire
Mitochondria: practical protocols, 51-66, 2007
Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans
LI Grad, LC Sayles, BD Lemire
Proceedings of the National Academy of Sciences 102 (51), 18367-18372, 2005
Locally released retinoic acid repatterns the first branchial arch cartilages in vivo
MR Plant, MP MacDonald, LI Grad, SJ Ritchie, JM Richman
Developmental biology 222 (1), 12-26, 2000
Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and …
LI Grad, AT Descheneau, W Neupert, R Lill, FE Nargang
Current genetics 36, 137-146, 1999
Intercellular prion-like conversion and transmission of Cu/Zn superoxide dismutase (SOD1) in cell culture
LI Grad, E Pokrishevsky, NR Cashman
Prions: Methods and Protocols, 357-367, 2017
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