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Paul Muchowski
Paul Muchowski
Verified email at gladstone.ucsf.edu
Title
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Cited by
Year
Kynurenines in the mammalian brain: when physiology meets pathology
R Schwarcz, JP Bruno, PJ Muchowski, HQ Wu
Nature Reviews Neuroscience 13 (7), 465-477, 2012
13302012
Modulation of neurodegeneration by molecular chaperones
PJ Muchowski, JL Wacker
Nature Reviews Neuroscience 6 (1), 11-22, 2005
12582005
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
PJ Muchowski, G Schaffar, A Sittler, EE Wanker, MK Hayer-Hartl, FU Hartl
Proceedings of the National Academy of Sciences 97 (14), 7841-7846, 2000
8052000
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein
S Willingham, TF Outeiro, MJ DeVit, SL Lindquist, PJ Muchowski
Science 302 (5651), 1769-1772, 2003
5302003
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
D Zwilling, SY Huang, KV Sathyasaikumar, FM Notarangelo, P Guidetti, ...
Cell 145 (6), 863-874, 2011
5172011
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ...
Journal of Biological Chemistry 282 (33), 23818-23828, 2007
5002007
Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
4612006
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
F Giorgini, P Guidetti, QV Nguyen, SC Bennett, PJ Muchowski
Nature genetics 37 (5), 526-531, 2005
4092005
Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?
PJ Muchowski
Neuron 35 (1), 9-12, 2002
4042002
Flanking sequences profoundly alter polyglutamine toxicity in yeast
ML Duennwald, S Jagadish, PJ Muchowski, S Lindquist
Proceedings of the National Academy of Sciences 103 (29), 11045-11050, 2006
3502006
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer
JL Wacker, MH Zareie, H Fong, M Sarikaya, PJ Muchowski
Nature structural & molecular biology 11 (12), 1215-1222, 2004
3492004
Small heat-shock proteins and their potential role in human disease
JI Clark, PJ Muchowski
Current opinion in structural biology 10 (1), 52-59, 2000
3332000
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease
S Campesan, EW Green, C Breda, KV Sathyasaikumar, PJ Muchowski, ...
Current Biology 21 (11), 961-966, 2011
2752011
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo
J Legleiter, E Mitchell, GP Lotz, E Sapp, C Ng, M DiFiglia, LM Thompson, ...
Journal of Biological Chemistry 285 (19), 14777-14790, 2010
2372010
Identifying polyglutamine protein species in situ that best predict neurodegeneration
J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ...
Nature chemical biology 7 (12), 925-934, 2011
2362011
ATP-enhanced molecular chaperone functions of the small heat shock protein human αB crystallin
PJ Muchowski, JI Clark
Proceedings of the National Academy of Sciences 95 (3), 1004-1009, 1998
1931998
The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro.
MD Perng, PJ Muchowski, P van Den IJssel, GJ Wu, AM Hutcheson, ...
The Journal of biological chemistry 274 (47), 33235-33243, 1999
1871999
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease
K Trinh, K Moore, PD Wes, PJ Muchowski, J Dey, L Andrews, LJ Pallanck
Journal of Neuroscience 28 (2), 465-472, 2008
1772008
Of mice, rats and men: revisiting the quinolinic acid hypothesis of Huntington's disease
R Schwarcz, P Guidetti, KV Sathyasaikumar, PJ Muchowski
Progress in neurobiology 90 (2), 230-245, 2010
1732010
A network of protein interactions determines polyglutamine toxicity
ML Duennwald, S Jagadish, F Giorgini, PJ Muchowski, S Lindquist
Proceedings of the National Academy of Sciences 103 (29), 11051-11056, 2006
1732006
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