Anton Rosenbaum
Anton Rosenbaum
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells
AI Rosenbaum, G Zhang, JD Warren, FR Maxfield
Proceedings of the National Academy of Sciences 107 (12), 5477-5482, 2010
2442010
Nieman Pick C Disease: Molecular Mechanisms and Potential Therapeutic Approaches
AI Rosenbaum, FR Maxfield, C Niemann-Pick Type
J. Neurochem 116, 789-795, 2011
2392011
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann− Pick type C disease therapeutics
AI Rosenbaum, CC Cosner, CJ Mariani, FR Maxfield, O Wiest, P Helquist
Journal of medicinal chemistry 53 (14), 5281-5289, 2010
832010
Chemical screen to reduce sterol accumulation in Niemann–Pick C disease cells identifies novel lysosomal acid lipase inhibitors
AI Rosenbaum, M Rujoi, AY Huang, H Du, GA Grabowski, FR Maxfield
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2009
512009
Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann−Pick Type C Disease Therapeutics
CC Cosner, JT Markiewicz, P Bourbon, CJ Mariani, O Wiest, M Rujoi, ...
Journal of medicinal chemistry 52 (20), 6494-6498, 2009
332009
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 …
J Welink, Y Xu, E Yang, A Wilson, N Henderson, L Luo, S Fraser, U Kavita, ...
Bioanalysis 10 (22), 1781-1801, 2018
172018
Multiplex LC-MS/MS assays for clinical bioanalysis of MEDI4276, an antibody-drug conjugate of tubulysin analogue attached via cleavable linker to a biparatopic humanized …
M Faria, M Peay, B Lam, E Ma, M Yuan, M Waldron, WR Mylott, M Liang, ...
Antibodies 8 (1), 11, 2019
132019
ADME considerations and bioanalytical strategies for pharmacokinetic assessments of antibody-drug conjugates
S Mou, Y Huang, AI Rosenbaum
Antibodies 7 (4), 41, 2018
112018
Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine …
Y Huang, CJ Del Nagro, K Balic, WR Mylott Jr, OA Ismaiel, E Ma, M Faria, ...
Analytical chemistry 92 (16), 11135-11144, 2020
62020
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial
JE Le Lay, Q Du, MB Mehta, N Bhagroo, BT Hummer, J Falloon, ...
Science Translational Medicine 13 (590), 2021
12021
Effects of a Neutralising Endothelial Lipase Monoclonal Antibody on Lipoprotein Metabolism in Nonhuman Primates and Healthy Volunteers
J Grimsby, J Falloon, M Damschroder, J Le Lay, G Carlson, T Hummer, ...
Circulation 140 (Suppl_1), A14373-A14373, 2019
12019
LEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic Effects of the Anti-Endothelial Lipase Antibody MEDI5884 in Subjects With Stable CAD
CT Ruff, JS Grimsby, A Rosenbaum, CY Jin, LF Tsai, S Karathanasis, ...
Circulation 140 (Suppl_1), A12342-A12342, 2019
12019
Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization
Y Huang, R Mu, D Wen, JS Grimsby, M Liang, AI Rosenbaum
Plos one 16 (6), e0252426, 2021
2021
ENDOTHELIAL LIPASE ANTIBODIES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
AI GRIMSBY, Joseph Samuel JIN, Chao-Yu FALLOON, Judith HSIA, Judith Ann ...
US Patent App. PCT/US2020/05,945, 2021
2021
Characterization of Antibody–Drug Conjugate Pharmacokinetics and in Vivo Biotransformation Using Quantitative Intact LC-HRMS and Surrogate Analyte LC-MRM
Y Huang, S Mou, Y Wang, R Mu, M Liang, AI Rosenbaum
Analytical Chemistry 93 (15), 6135-6144, 2021
2021
Phase I Study of MEDI3726: A Prostate-Specific Membrane Antigen-Targeted Antibody–Drug Conjugate, in Patients with mCRPC after Failure of Abiraterone or Enzalutamide
JS de Bono, MT Fleming, JS Wang, R Cathomas, MS Miralles, J Bothos, ...
Clinical Cancer Research, 2021
2021
First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody-Drug Conjugate MEDI4276 in Patients with HER2+ Advanced Breast or Gastric Cancer
MD Pegram, EP Hamilton, AR Tan, AM Storniolo, K Balic, AI Rosenbaum, ...
Molecular Cancer Therapeutics, 2021
2021
Bioanalytical Methods Addressing Rising Complexity of Novel Modalities and Novel Delivery Routes for Biotherapeutics; https://informaconnect.com/next-gen-protein/
AI Rosenbaum
Next Generation Protein Therapeutics Summit, 2020
2020
2019 World ADC Summit: Bioanalysis Day summary; http://www.bioanalysis-zone.com/2019/12/
AI Rosenbaum
World ADC Summit, 2019
2019
Quantitative High Resolution Mass Spectrometry Coming of Age
AI Rosenbaum, H Yue
Bioanalysis Zone, 2016
2016
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