Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour O Hernández-Hernández, C Guiraud-Dogan, G Sicot, A Huguet, S Luilier, ... Brain 136 (3), 957-970, 2013 | 86 | 2013 |
Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist TM Ballard, S Sänger, GA Higgins European journal of pharmacology 412 (3), 255-264, 2001 | 70 | 2001 |
Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I) F Metzger, W Sajid, S Saenger, C Staudenmaier, C van der Poel, ... Journal of Biological Chemistry 286 (22), 19501-19510, 2011 | 50 | 2011 |
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function MR Pitcher, CS Ward, EM Arvide, CA Chapleau, L Pozzo-Miller, ... Human Molecular Genetics 22 (13), 2626-2633, 2013 | 47 | 2013 |
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1 F Krieger, N Elflein, S Saenger, E Wirthgen, K Rak, S Frantz, A Hoeflich, ... Brain 137 (5), 1374-1393, 2014 | 41 | 2014 |
PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders S Saenger, C Goeldner, JR Frey, L Ozmen, S Ostrowitzki, W Spooren, ... Growth Hormone & IGF Research 21 (5), 292-303, 2011 | 35 | 2011 |
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity S Saenger, B Holtmann, MR Nilges, S Schroeder, A Hoeflich, H Kletzl, ... Amyotrophic lateral sclerosis 13 (5), 418-429, 2012 | 32 | 2012 |
Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes N Hellbach, S Peterson, D Haehnke, A Shankar, S LaBarge, C Pivaroff, ... PLoS One 13 (10), e0205589, 2018 | 25 | 2018 |
PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia K Parker, A Berretta, S Saenger, M Sivaramakrishnan, SA Shirley, ... Scientific Reports 7 (1), 241, 2017 | 19 | 2017 |
Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury KJB Martins, SM Gehrig, T Naim, S Saenger, D Baum, F Metzger, ... Growth Hormone & IGF Research 23 (4), 128-133, 2013 | 15 | 2013 |
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin–Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic … N Schindler, J Mayer, S Saenger, U Gimsa, C Walz, J Brenmoehl, D Ohde, ... Growth Hormone & IGF Research 33, 1-8, 2017 | 13 | 2017 |
Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury DM Sama, SW Carlson, B Joseph, S Saenger, F Metzger, KE Saatman Restorative neurology and neuroscience 36 (4), 559-569, 2018 | 11 | 2018 |
PEGylation of lysine residues reduces the pro-migratory activity of IGF-I M Sivaramakrishnan, AS Kashyap, B Amrein, S Saenger, S Meier, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (10), 4734-4742, 2013 | 11 | 2013 |
Skeletal muscle dysfunction and mitochondrial deficits in spinal muscular atrophy (SMA) N Hellbach, KD McCarthy, S Saenger, S Peterson, U Schmidt, S Paushkin, ... Neuromuscular Disorders 1 (27), S30, 2017 | 1 | 2017 |
PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia A Clarkson, A Berretta, F Metzger, K Parker, S Saenger, SA Shirley, ... Nature Publishing Group, 2017 | | 2017 |
OR2-3: The Cardin-Weintraub Motif present in IGFBP-2 is required for growth and function of the mouse brain N Schindler, J Mayer, T Kirschstein, S Saenger, U Gimsa, J Brenmoehl, ... Growth Hormone & IGF Research, S8, 2014 | | 2014 |
P02-33 Intramuscular administration of PEGylated IGF-I accelerates skeletal muscle regeneration after myotoxic injury F Metzger, KJ Martins, SM Gehrig, T Naim, S Saenger, D Baum, GS Lynch Growth Hormone & IGF Research, S54-S55, 2012 | | 2012 |
P78 Elimination of acute drug side effects without loss of efficacy by site-specific PEGylation of insulin-like growth factor I F Metzger, C Staudenmaier, S Saenger, A Schuler, W Sajid, F Hesse, ... Growth Hormone & IGF Research, S67, 2010 | | 2010 |