Alexei Toutchkine
Alexei Toutchkine
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Activation of endogenous Cdc42 visualized in living cells
P Nalbant, L Hodgson, V Kraynov, A Toutchkine, KM Hahn
Science 305 (5690), 1615-1619, 2004
Efficient syntheses of diverse, medicinally relevant targets planned by computer and executed in the laboratory
T Klucznik, B Mikulak-Klucznik, M McCormack, H Lima, S Szymkuc, ...
Chem 4 (3), 522-532, 2018
Solvent-sensitive dyes to report protein conformational changes in living cells
A Toutchkine, V Kraynov, K Hahn
Journal of the American Chemical Society 125 (14), 4132-4145, 2003
Merocyanine dyes with improved photostability
A Toutchkine, DV Nguyen, KM Hahn
Organic letters 9 (15), 2775-2777, 2007
A theoretical study of the UV/visible absorption and emission solvatochromic properties of solvent‐sensitive dyes
WG Han, T Liu, F Himo, A Toutchkine, D Bashford, KM Hahn, ...
ChemPhysChem 4 (10), 1084-1094, 2003
A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics
SC Garrett, L Hodgson, A Rybin, A Toutchkine, KM Hahn, DS Lawrence, ...
Biochemistry 47 (3), 986-996, 2008
Live-cell fluorescent biosensors for activated signaling proteins
K Hahn, A Toutchkine
Current opinion in cell biology 14 (2), 167-172, 2002
Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia
Q Wang, EI Zimmerman, A Toutchkine, TD Martin, LM Graves, ...
ACS Chemical biology 5 (9), 887-895, 2010
Density functional vertical self-consistent reaction field theory for solvatochromism studies of solvent-sensitive dyes
T Liu, WG Han, F Himo, GM Ullmann, D Bashford, A Toutchkine, KM Hahn, ...
The Journal of Physical Chemistry A 108 (16), 3545-3555, 2004
Single-Molecule Study of Protein− Protein Interaction Dynamics in a Cell Signaling System
X Tan, P Nalbant, A Toutchkine, D Hu, ER Vorpagel, KM Hahn, HP Lu
The Journal of Physical Chemistry B 108 (2), 737-744, 2004
Facile synthesis of thiol-reactive Cy3 and Cy5 derivatives with enhanced water solubility
A Toutchkine, P Nalbant, KM Hahn
Bioconjugate chemistry 13 (3), 387-391, 2002
Substituent-Dictated Partitioning of Intermediates on the Sulfide Singlet Oxygen Reaction Surface. A New Mechanism for Oxidative C− S Bond Cleavage in α-Hydroperoxy Sulfides
A Toutchkine, D Aebisher, EL Clennan
Journal of the American Chemical Society 123 (21), 4966-4973, 2001
The Reactions of O2 (1Δg) with Anancomeric 1,3-Dithianes. The First Experimental Evidence in Support of a Hydroperoxy Sulfonium Ylide as a Precursor to …
A Toutchkine, EL Clennan
The Journal of Organic Chemistry 64 (15), 5620-5625, 1999
Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging
A Toutchkine, DV Nguyen, KM Hahn
Bioconjugate chemistry 18 (4), 1344-1348, 2007
A new mechanism for oxidative C− S bond cleavage during reactions of singlet oxygen with organic sulfides: electronically dictated reaction selectivity in the persulfoxide …
A Toutchkine, EL Clennan
Journal of the American Chemical Society 122 (8), 1834-1835, 2000
Experimental and DFT studies: novel structural modifications greatly enhance the solvent sensitivity of live cell imaging dyes
A Toutchkine, WG Han, M Ullmann, T Liu, D Bashford, L Noodleman, ...
The Journal of Physical Chemistry A 111 (42), 10849-10860, 2007
Ratiometric imaging using a single dye enables simultaneous visualization of Rac1 and Cdc42 activation
CJ MacNevin, A Toutchkine, DJ Marston, CW Hsu, D Tsygankov, L Li, ...
Journal of the American Chemical Society 138 (8), 2571-2575, 2016
Simultaneous fluorescent monitoring of proteasomal subunit catalysis
A Wakata, HM Lee, P Rommel, A Toutchkine, M Schmidt, DS Lawrence
Journal of the American Chemical Society 132 (5), 1578-1582, 2010
The reactions of singlet oxygen with β-chlorosulfides. The role of hydroperoxy sulfonium ylides in the oxidative destruction of chemical warfare simulants
A Toutchkine, EL Clennan
Tetrahedron letters 40 (36), 6519-6522, 1999
Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
KM Hahn, A Toutchkine
US Patent 6,951,947, 2005
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