| Activation of endogenous Cdc42 visualized in living cells P Nalbant, L Hodgson, V Kraynov, A Toutchkine, KM Hahn Science 305 (5690), 1615-1619, 2004 | 447 | 2004 |
| Efficient syntheses of diverse, medicinally relevant targets planned by computer and executed in the laboratory T Klucznik, B Mikulak-Klucznik, M McCormack, H Lima, S Szymkuc, ... Chem 4 (3), 522-532, 2018 | 315 | 2018 |
| Solvent-sensitive dyes to report protein conformational changes in living cells A Toutchkine, V Kraynov, K Hahn Journal of the American Chemical Society 125 (14), 4132-4145, 2003 | 192 | 2003 |
| A theoretical study of the UV/visible absorption and emission solvatochromic properties of solvent‐sensitive dyes WG Han, T Liu, F Himo, A Toutchkine, D Bashford, KM Hahn, ... ChemPhysChem 4 (10), 1084-1094, 2003 | 119 | 2003 |
| Merocyanine dyes with improved photostability A Toutchkine, DV Nguyen, KM Hahn Organic letters 9 (15), 2775-2777, 2007 | 116 | 2007 |
| A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics SC Garrett, L Hodgson, A Rybin, A Toutchkine, KM Hahn, DS Lawrence, ... Biochemistry 47 (3), 986-996, 2008 | 92 | 2008 |
| Live-cell fluorescent biosensors for activated signaling proteins K Hahn, A Toutchkine Current opinion in cell biology 14 (2), 167-172, 2002 | 65 | 2002 |
| Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia Q Wang, EI Zimmerman, A Toutchkine, TD Martin, LM Graves, ... ACS Chemical biology 5 (9), 887-895, 2010 | 63 | 2010 |
| Density functional vertical self-consistent reaction field theory for solvatochromism studies of solvent-sensitive dyes T Liu, WG Han, F Himo, GM Ullmann, D Bashford, A Toutchkine, KM Hahn, ... The Journal of Physical Chemistry A 108 (16), 3545-3555, 2004 | 63 | 2004 |
| Single-Molecule Study of Protein− Protein Interaction Dynamics in a Cell Signaling System X Tan, P Nalbant, A Toutchkine, D Hu, ER Vorpagel, KM Hahn, HP Lu The Journal of Physical Chemistry B 108 (2), 737-744, 2004 | 62 | 2004 |
| Facile synthesis of thiol-reactive Cy3 and Cy5 derivatives with enhanced water solubility A Toutchkine, P Nalbant, KM Hahn Bioconjugate chemistry 13 (3), 387-391, 2002 | 53 | 2002 |
| Substituent-Dictated Partitioning of Intermediates on the Sulfide Singlet Oxygen Reaction Surface. A New Mechanism for Oxidative C− S Bond Cleavage in α-Hydroperoxy Sulfides A Toutchkine, D Aebisher, EL Clennan Journal of the American Chemical Society 123 (21), 4966-4973, 2001 | 52 | 2001 |
| The Reactions of O2 (1Δg) with Anancomeric 1,3-Dithianes. The First Experimental Evidence in Support of a Hydroperoxy Sulfonium Ylide as a Precursor to … A Toutchkine, EL Clennan The Journal of Organic Chemistry 64 (15), 5620-5625, 1999 | 40 | 1999 |
| Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging A Toutchkine, DV Nguyen, KM Hahn Bioconjugate chemistry 18 (4), 1344-1348, 2007 | 35 | 2007 |
| A new mechanism for oxidative C− S bond cleavage during reactions of singlet oxygen with organic sulfides: electronically dictated reaction selectivity in the persulfoxide … A Toutchkine, EL Clennan Journal of the American Chemical Society 122 (8), 1834-1835, 2000 | 35 | 2000 |
| Experimental and DFT studies: novel structural modifications greatly enhance the solvent sensitivity of live cell imaging dyes A Toutchkine, WG Han, M Ullmann, T Liu, D Bashford, L Noodleman, ... The Journal of Physical Chemistry A 111 (42), 10849-10860, 2007 | 31 | 2007 |
| Ratiometric imaging using a single dye enables simultaneous visualization of Rac1 and Cdc42 activation CJ MacNevin, A Toutchkine, DJ Marston, CW Hsu, D Tsygankov, L Li, ... Journal of the American Chemical Society 138 (8), 2571-2575, 2016 | 27 | 2016 |
| Simultaneous fluorescent monitoring of proteasomal subunit catalysis A Wakata, HM Lee, P Rommel, A Toutchkine, M Schmidt, DS Lawrence Journal of the American Chemical Society 132 (5), 1578-1582, 2010 | 26 | 2010 |
| The reactions of singlet oxygen with β-chlorosulfides. The role of hydroperoxy sulfonium ylides in the oxidative destruction of chemical warfare simulants A Toutchkine, EL Clennan Tetrahedron letters 40 (36), 6519-6522, 1999 | 22 | 1999 |
| Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation KM Hahn, A Toutchkine US Patent 6,951,947, 2005 | 20 | 2005 |
Klaus M HahnProfessor of Pharmacology, University of North Carolina Chapel HillVerified email at med.unc.edu
