| Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory … H Chu, JFW Chan, TTT Yuen, H Shuai, S Yuan, Y Wang, B Hu, CCY Yip, ... The Lancet Microbe 1 (1), e14-e23, 2020 | 850 | 2020 |
| Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19 H Chu, JFW Chan, Y Wang, TTT Yuen, Y Chai, Y Hou, H Shuai, D Yang, ... Clinical Infectious Diseases 71 (6), 1400-1409, 2020 | 732 | 2020 |
| Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron H Shuai, JFW Chan, B Hu, Y Chai, TTT Yuen, F Yin, X Huang, C Yoon, ... Nature 603 (7902), 693-699, 2022 | 512 | 2022 |
| Attenuated interferon and proinflammatory response in SARS-CoV-2–infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation D Yang, H Chu, Y Hou, Y Chai, H Shuai, ACY Lee, X Zhang, Y Wang, ... The Journal of infectious diseases 222 (5), 734-745, 2020 | 193 | 2020 |
| Host and viral determinants for efficient SARS-CoV-2 infection of the human lung H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang, H Shuai, D Yang, Y Hou, ... Nature communications 12 (1), 134, 2021 | 129 | 2021 |
| Emerging SARS-CoV-2 variants expand species tropism to murines H Shuai, JFW Chan, TTT Yuen, C Yoon, JC Hu, L Wen, B Hu, D Yang, ... EBioMedicine 73, 2021 | 123 | 2021 |
| Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity H Chu, H Shuai, Y Hou, X Zhang, L Wen, X Huang, B Hu, D Yang, ... Science advances 7 (25), eabf8577, 2021 | 60 | 2021 |
| Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2 B Hu, JFW Chan, H Liu, Y Liu, Y Chai, J Shi, H Shuai, Y Hou, X Huang, ... Emerging Microbes & Infections 11 (1), 2275-2287, 2022 | 55 | 2022 |
| Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer H Shuai, H Chu, Y Hou, D Yang, Y Wang, B Hu, X Huang, X Zhang, ... Journal of Infection 81 (4), e1-e10, 2020 | 49 | 2020 |
| SARS-CoV-2 induces a more robust innate immune response and replicates less efficiently than SARS-CoV in the human intestines: an ex vivo study with implications on … H Chu, JFW Chan, Y Wang, TTT Yuen, Y Chai, H Shuai, D Yang, B Hu, ... Cellular and molecular gastroenterology and hepatology 11 (3), 771-781, 2021 | 47 | 2021 |
| Coronaviruses exploit a host cysteine-aspartic protease for replication H Chu, Y Hou, D Yang, L Wen, H Shuai, C Yoon, J Shi, Y Chai, TTT Yuen, ... Nature 609 (7928), 785-792, 2022 | 43 | 2022 |
| Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice BZ Zhang, H Shuai, HR Gong, JC Hu, B Yan, TTT Yuen, YF Hu, C Yoon, ... JCI insight 7 (11), 2022 | 33 | 2022 |
| Virological features and pathogenicity of SARS-CoV-2 Omicron BA. 2 JFW Chan, B Hu, Y Chai, H Shuai, H Liu, J Shi, Y Liu, C Yoon, J Zhang, ... Cell Reports Medicine 3 (9), 2022 | 26 | 2022 |
| Low environmental temperature exacerbates severe acute respiratory syndrome coronavirus 2 infection in golden Syrian hamsters JFW Chan, VKM Poon, CCS Chan, KKH Chik, JOL Tsang, Z Zou, ... Clinical Infectious Diseases 75 (1), e1101-e1111, 2022 | 18 | 2022 |
| Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation LY Ng, HT Ma, JCY Liu, X Huang, N Lee, RYC Poon Cell Cycle 18 (2), 238-248, 2019 | 16 | 2019 |
| The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5 H Shuai, JFW Chan, B Hu, Y Chai, C Yoon, H Liu, Y Liu, J Shi, T Zhu, ... EBioMedicine 95, 2023 | 15 | 2023 |
| STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells D Yang, H Chu, G Lu, H Shuai, Y Wang, Y Hou, X Zhang, X Huang, B Hu, ... Emerging microbes & infections 10 (1), 1024-1037, 2021 | 15 | 2021 |
| Altered host protease determinants for SARS-CoV-2 Omicron JFW Chan, X Huang, B Hu, Y Chai, H Shi, T Zhu, TTT Yuen, Y Liu, H Liu, ... Science Advances 9 (3), eadd3867, 2023 | 14 | 2023 |
| Targeting ACLY efficiently inhibits SARS-CoV-2 replication TTT Yuen, JFW Chan, B Yan, CCY Shum, Y Liu, H Shuai, Y Hou, X Huang, ... International Journal of Biological Sciences 18 (12), 4714, 2022 | 7 | 2022 |
| Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA. 2/5 subvariants in the upper and lower respiratory tract B Hu, JFW Chan, Y Liu, H Liu, YX Chen, H Shuai, YF Hu, M Hartnoll, ... EBioMedicine 99, 2024 | 2 | 2024 |
Hin ChuDepartment of Microbiology, The University of Hong KongVerified email at HKU.hk
