| A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function DM Anderson, E Maraskovsky, WL Billingsley, WC Dougall, ME Tometsko, ... Nature 390 (6656), 175-179, 1997 | 2980 | 1997 |
| RANK is essential for osteoclast and lymph node development WC Dougall, M Glaccum, K Charrier, K Rohrbach, K Brasel, T De Smedt, ... Genes & development 13 (18), 2412-2424, 1999 | 1808 | 1999 |
| The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain MA Degli-Esposti, WC Dougall, PJ Smolak, JY Waugh, CA Smith, ... Immunity 7 (6), 813-820, 1997 | 1117 | 1997 |
| Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab DL Lacey, WJ Boyle, WS Simonet, PJ Kostenuik, WC Dougall, JK Sullivan, ... Nature reviews Drug discovery 11 (5), 401-419, 2012 | 743 | 2012 |
| RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis E Gonzalez-Suarez, AP Jacob, J Jones, R Miller, MP Roudier-Meyer, ... Nature 468 (7320), 103-107, 2010 | 618 | 2010 |
| Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock‐in mice that express chimeric (murine/human) RANKL PJ Kostenuik, HQ Nguyen, J McCabe, KS Warmington, C Kurahara, ... Journal of Bone and Mineral Research 24 (2), 182-195, 2009 | 503 | 2009 |
| The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily L Galibert, ME Tometsko, DM Anderson, D Cosman, WC Dougall Journal of Biological Chemistry 273 (51), 34120-34127, 1998 | 450 | 1998 |
| TIGIT and CD 96: new checkpoint receptor targets for cancer immunotherapy WC Dougall, S Kurtulus, MJ Smyth, AC Anderson Immunological reviews 276 (1), 112-120, 2017 | 412 | 2017 |
| A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function AP Armstrong, ME Tometsko, M Glaccum, CL Sutherland, D Cosman, ... Journal of Biological Chemistry 277 (46), 44347-44356, 2002 | 328 | 2002 |
| The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies. WC Dougall, X Qian, NC Peterson, MJ Miller, A Samanta, MI Greene Oncogene 9 (8), 2109-2123, 1994 | 323 | 1994 |
| RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, ... Nature medicine 22 (8), 933-939, 2016 | 269 | 2016 |
| TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma C Guillerey, H Harjunpää, N Carrié, S Kassem, T Teo, K Miles, ... Blood, The Journal of the American Society of Hematology 132 (16), 1689-1694, 2018 | 252 | 2018 |
| Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis JR Canon, M Roudier, R Bryant, S Morony, M Stolina, PJ Kostenuik, ... Clinical & experimental metastasis 25, 119-129, 2008 | 244 | 2008 |
| The RANK/RANKL/OPG triad in cancer-induced bone diseases WC Dougall, M Chaisson Cancer and Metastasis Reviews 25 (4), 541-549, 2006 | 241 | 2006 |
| RANKL acts directly on RANK‐expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes AP Armstrong, RE Miller, JC Jones, J Zhang, ET Keller, WC Dougall The Prostate 68 (1), 92-104, 2008 | 240 | 2008 |
| Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis WC Dougall Clinical Cancer Research 18 (2), 326-335, 2012 | 237 | 2012 |
| Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. X Qian, CM LeVea, JK Freeman, WC Dougall, MI Greene Proceedings of the National Academy of Sciences 91 (4), 1500-1504, 1994 | 228 | 1994 |
| RANK induces epithelial–mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis M Palafox, I Ferrer, P Pellegrini, S Vila, S Hernandez-Ortega, ... Cancer research 72 (11), 2879-2888, 2012 | 220 | 2012 |
| Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy SJ Blake, WC Dougall, JJ Miles, MWL Teng, MJ Smyth Clinical Cancer Research 22 (21), 5183-5188, 2016 | 219 | 2016 |
| Progesterone/RANKL is a major regulatory axis in the human breast T Tanos, G Sflomos, PC Echeverria, A Ayyanan, M Gutierrez, JF Delaloye, ... Science translational medicine 5 (182), 182ra55-182ra55, 2013 | 211 | 2013 |
Eva Gonzalez SuarezPrincipal Investigator CNIOVerified email at cnio.es
