| Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids H Raj, W Szymański, J De Villiers, HJ Rozeboom, VP Veetil, CR Reis, ... Nature Chemistry 4 (6), 478-484, 2012 | 97 | 2012 |
| Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development. WJA Moolman, M De Villiers, E Strauss Biochemical Society Transactions 42 (4), 1080-1086, 2014 | 71 | 2014 |
| Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity M de Villiers, C Macuamule, C Spry, YM Hyun, E Strauss, KJ Saliba ACS medicinal chemistry letters 4 (8), 784-789, 2013 | 70 | 2013 |
| Refugia, dispersal and divergence in a forest archipelago: a study of Streptocarpus in eastern South Africa M Hughes, M Möller, DU Bellstedt, TJ Edwards, M De Villiers Molecular Ecology 14 (14), 4415-4426, 2005 | 66 | 2005 |
| Catalytic mechanisms and biocatalytic applications of aspartate and methylaspartate ammonia lyases M de Villiers, V Puthan Veetil, H Raj, J de Villiers, GJ Poelarends ACS chemical biology 7 (10), 1618-1628, 2012 | 59 | 2012 |
| A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity CJ Macuamule, ET Tjhin, CE Jana, L Barnard, L Koekemoer, M De Villiers, ... Antimicrobial agents and chemotherapy 59 (6), 3666-3668, 2015 | 50 | 2015 |
| Kinetic Variation in Bacterial Pantothenate Kinases Determines Pantothenamide Mode of Action and Impacts on Coenzyme A Salvage Biosynthesis. M De Villiers, L Barnard, L Koekemoer, L Snoep, Jacky, E Strauss FEBS Journal 281 (20), 4731-4753, 2014 | 45* | 2014 |
| Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency I Di Meo, C Colombelli, B Srinivasan, M De Villiers, J Hamada, SY Jeong, ... Scientific reports 7 (1), 11260, 2017 | 32 | 2017 |
| Antiplasmodial mode of action of pantothenamides: pantothenate kinase serves as a metabolic activator not as a target M de Villiers, C Spry, CJ Macuamule, L Barnard, G Wells, KJ Saliba, ... ACS Infectious Diseases 3 (7), 527-541, 2017 | 32 | 2017 |
| Biocatalytic production of coenzyme A analogues E Strauss, M de Villiers, I Rootman ChemCatChem 2 (8), 929-937, 2010 | 32 | 2010 |
| Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of Coenzyme A biosynthesis and utilization M Van Wyk, E Strauss Organic Biomolecular Chemistry 6, 4348-4355, 2008 | 27 | 2008 |
| One-pot preparation of Coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons, M Van Wyk, E Strauss Chemical Communications, 398-400, 2007 | 27 | 2007 |
| Enantioselective synthesis of N-substituted aspartic acids using an engineered variant of methylaspartate ammonia lyase VP Veetil, H Raj, MD Villiers, PG Tepper, FJ Dekker, WJ Quax, ... ChemCatChem Commun 5, 1325-7, 2013 | 24 | 2013 |
| Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide C Spry, L Barnard, M Kok, AK Powell, D Mahesh, ET Tjhin, KJ Saliba, ... ACS Infectious Diseases 6 (7), 1844-1854, 2020 | 21 | 2020 |
| Chemoenzymatic Synthesis of ortho‐, meta‐, and para‐Substituted Derivatives of L‐threo‐3‐Benzyloxyaspartate, An Important Glutamate Transporter Blocker J de Villiers, M de Villiers, EM Geertsema, H Raj, GJ Poelarends ChemCatChem 7 (13), 1931-1934, 2015 | 18 | 2015 |
| Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future ML Stofberg, C Caillet, M de Villiers, T Zininga Cells 10 (11), 2849, 2021 | 15 | 2021 |
| GJ Poelarend s, ACS Chem M De Villiers, VP Veetil, H Raj, J De Villiers Biol 7, 1618-1628, 2012 | 9 | 2012 |
| Creating Cellulose‐Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor‐Based Biotransformations I Rootman, M de Villiers, LA Brand, E Strauss ChemCatChem 2 (10), 1239-1251, 2010 | 9 | 2010 |
| Jump-starting CoA biosynthesis M De Villiers, E Strauss Nature chemical biology 11 (10), 757-758, 2015 | 6 | 2015 |
| Antiplasmodial mode of action of pantothenamides: pantothenate kinase serves as a metabolic activator not as a target. ACS Infect Dis. 2017; 3: 527–541 M De Villiers, C Spry, CJ Macuamule, L Barnard, G Wells, KJ Saliba Epub 2017/04/25. https://doi. org/10.1021/acsinfecdis. 7b00024 PMID: 28437604, 0 | 6 | |
