Weiming Xia
Weiming Xia
Boston University School of Medicine
Verified email at - Homepage
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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
MS Wolfe, W Xia, BL Ostaszewski, TS Diehl, WT Kimberly, DJ Selkoe
Nature 398 (6727), 513-517, 1999
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ...
Nature medicine 3 (1), 67-72, 1997
Skeletal and CNS defects in Presenilin-1-deficient mice
J Shen, RT Bronson, DF Chen, W Xia, DJ Selkoe, S Tonegawa
Cell 89 (4), 629-639, 1997
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ...
Nature medicine 9 (1), 3-4, 2003
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
WP Esler, WT Kimberly, BL Ostaszewski, TS Diehl, CL Moore, JY Tsai, ...
Nature cell biology 2 (7), 428-434, 2000
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
A Salehi, JD Delcroix, PV Belichenko, K Zhan, C Wu, JS Valletta, ...
Neuron 51 (1), 29-42, 2006
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
L Pastorino, A Sun, PJ Lu, XZ Zhou, M Balastik, G Finn, G Wulf, J Lim, ...
Nature 440 (7083), 528-534, 2006
Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Aβ42
RG Perez, S Soriano, JD Hayes, B Ostaszewski, W Xia, DJ Selkoe, ...
Journal of Biological Chemistry 274 (27), 18851-18856, 1999
APP processing is regulated by cytoplasmic phosphorylation
MS Lee, SC Kao, CA Lemere, W Xia, HC Tseng, Y Zhou, R Neve, ...
The Journal of cell biology 163 (1), 83-95, 2003
A detergent-insoluble membrance compartment contains Aβ in vivo
SJ Lee, U Liyanage, PE Bickel, W Xia, PT Lansbury Jr, KS Kosik
Nature medicine 4 (6), 730-734, 1998
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291and Ala299and occur as stable N-and C-terminal fragments in normal and Alzheimer brain tissue
MB Podlisny, M Citron, P Amarante, R Sherrington, W Xia, J Zhang, ...
Neurobiology of disease 3 (4), 325-337, 1997
Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease
MS Wolfe, W Xia, CL Moore, DD Leatherwood, B Ostaszewski, T Rahmati, ...
Biochemistry 38 (15), 4720-4727, 1999
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
WT Kimberly, W Xia, T Rahmati, MS Wolfe, DJ Selkoe
Journal of Biological Chemistry 275 (5), 3173-3178, 2000
Presenilin-mediated modulation of capacitative calcium entry
AS Yoo, I Cheng, S Chung, TZ Grenfell, H Lee, E Pack-Chung, M Handler, ...
Neuron 27 (3), 561-572, 2000
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins
W Xia, J Zhang, D Kholodenko, M Citron, MB Podlisny, DB Teplow, ...
Journal of Biological Chemistry 272 (12), 7977-7982, 1997
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
W Xia, J Zhang, R Perez, EH Koo, DJ Selkoe
Proceedings of the National Academy of Sciences 94 (15), 8208-8213, 1997
The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels
Y Dong, G Zhang, B Zhang, RD Moir, W Xia, ER Marcantonio, DJ Culley, ...
Archives of neurology 66 (5), 620-631, 2009
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid β-protein accumulation
Z Xie, Y Dong, U Maeda, RD Moir, W Xia, DJ Culley, G Crosby, RE Tanzi
Journal of Neuroscience 27 (6), 1247-1254, 2007
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
MS Wolfe, J De Los Angeles, DD Miller, W Xia, DJ Selkoe
Biochemistry 38 (35), 11223-11230, 1999
A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity
MS Wolfe, M Citron, TS Diehl, W Xia, IO Donkor, DJ Selkoe
Journal of medicinal chemistry 41 (1), 6-9, 1998
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