| Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for … F Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ... Journal of medicinal chemistry 54 (2), 635-654, 2011 | 326 | 2011 |
| Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts NH Pipalia, CC Cosner, A Huang, A Chatterjee, P Bourbon, N Farley, ... Proceedings of the National Academy of Sciences 108 (14), 5620-5625, 2011 | 249 | 2011 |
| Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer F Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ... Molecular and cellular biochemistry 356 (1), 37-43, 2011 | 159 | 2011 |
| Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells GL Pearson, N Mellett, KY Chu, J Cantley, A Davenport, P Bourbon, ... Diabetologia 57, 129-139, 2014 | 49 | 2014 |
| Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann−Pick Type C Disease Therapeutics CC Cosner, JT Markiewicz, P Bourbon, CJ Mariani, O Wiest, M Rujoi, ... Journal of medicinal chemistry 52 (20), 6494-6498, 2009 | 36 | 2009 |
| Novel potent pyrimido [4, 5-c] quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties F Pierre, SE O’Brien, M Haddach, P Bourbon, MK Schwaebe, E Stefan, ... Bioorganic & medicinal chemistry letters 21 (6), 1687-1691, 2011 | 35 | 2011 |
| Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives P Bourbon, Q Peng, G Ferraudi, C Stauffacher, O Wiest, P Helquist The Journal of Organic Chemistry 77 (6), 2756-2762, 2012 | 34 | 2012 |
| Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis SE Kamel Djaout, Vinayak Singh, Yap Boum, Victoria Katawera, Hubert F ... Sci. Rep. 6, 2016 | 33 | 2016 |
| Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery JS • Ekins, S., Madrid, P. B., Sarker, M., Li, S-G., Mittal, N., Wang, X ... Plos one 10, 1-20, 2015 | 21* | 2015 |
| Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide P Bourbon, Q Peng, G Ferraudi, C Stauffacher, O Wiest, P Helquist Bioorganic & medicinal chemistry letters 23 (23), 6321-6324, 2013 | 17 | 2013 |
| Synthesis and photochemical behavior of coumarin-caged cholesterol P Bourbon, Q Peng, G Ferraudi, C Stauffacher, O Wiest, P Helquist Bioorganic & medicinal chemistry letters 23 (7), 2162-2165, 2013 | 17 | 2013 |
| Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers M Avital-Shmilovici, X Liu, T Shaler, A Lowenthal, P Bourbon, J Snider, ... ACS Central Science 8 (1), 86-101, 2022 | 3 | 2022 |
| Mass spectrometry distinguishable synthetic compounds, libraries, and methods thereof P Madrid, N Collins, M Avital-Shmilovici, P Bourbon, T Shaler US Patent App. 16/644,565, 2021 | | 2021 |
| Topologically segregated polymer beads and methods thereof P Madrid, P Bourbon, M Avital-Shmilovici, N Collins US Patent 10,882,020, 2021 | | 2021 |
| Development of potential Niemann-Pick C therapeutics and the synthesis of caged nicotinamide and cholesterol to gain a better understanding of cholesterol biosynthesis and … P Bourbon University of Notre Dame, 2013 | | 2013 |
