| Overcoming EGFR (T790M) and EGFR (C797S) resistance with mutant-selective allosteric inhibitors Y Jia, CH Yun, E Park, D Ercan, M Manuia, J Juarez, C Xu, K Rhee, ... Nature 534 (7605), 129-132, 2016 | 781 | 2016 |
| Copper transport and its alterations in Menkes and Wilson diseases M DiDonato, B Sarkar Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1360 (1), 3-16, 1997 | 277 | 1997 |
| ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization M DiDonato, L Craig, ME Huff, MM Thayer, RMF Cardoso, CJ Kassmann, ... Journal of molecular biology 332 (3), 601-615, 2003 | 263 | 2003 |
| Inhibition of DYRK1A and GSK3B induces human β-cell proliferation W Shen, B Taylor, Q Jin, V Nguyen-Tran, S Meeusen, YQ Zhang, ... Nature communications 6 (1), 8372, 2015 | 217 | 2015 |
| Expression, purification, and metal binding properties of the N-terminal domain from the Wilson disease putative copper-transporting ATPase (ATP7B) M DiDonato, S Narindrasorasak, JR Forbes, DW Cox, B Sarkar Journal of Biological Chemistry 272 (52), 33279-33282, 1997 | 204 | 1997 |
| Superoxide Dismutase from the Eukaryotic Thermophile< i> Alvinella pompejana</i>: Structures, Stability, Mechanism, and Insights into Amyotrophic Lateral Sclerosis DS Shin, M DiDonato, DP Barondeau, GL Hura, C Hitomi, JA Berglund, ... Journal of molecular biology 385 (5), 1534-1555, 2009 | 138 | 2009 |
| Copper-induced conformational changes in the N-terminal domain of the Wilson disease copper-transporting ATPase M DiDonato, HF Hsu, S Narindrasorasak, L Que, B Sarkar Biochemistry 39 (7), 1890-1896, 2000 | 137 | 2000 |
| EGF816 exerts anticancer effects in non–small cell lung cancer by irreversibly and selectively targeting primary and acquired activating mutations in the EGF receptor Y Jia, J Juarez, J Li, M Manuia, MJ Niederst, C Tompkins, N Timple, ... Cancer research 76 (6), 1591-1602, 2016 | 126 | 2016 |
| Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu, Zn superoxide dismutase RMF Cardoso, MM Thayer, M DiDonato, TP Lo, CK Bruns, ED Getzoff, ... Journal of molecular biology 324 (2), 247-256, 2002 | 114 | 2002 |
| Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent … G Lelais, R Epple, TH Marsilje, YO Long, M McNeill, B Chen, W Lu, ... Journal of medicinal chemistry 59 (14), 6671-6689, 2016 | 111 | 2016 |
| Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase W Hur, A Velentza, S Kim, L Flatauer, X Jiang, D Valente, DE Mason, ... Bioorganic & medicinal chemistry letters 18 (22), 5916-5919, 2008 | 92 | 2008 |
| Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold C Rife, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, ... Proteins: Structure, Function, and Bioinformatics 61 (2), 449-453, 2005 | 62 | 2005 |
| Selective DYRK1A inhibitor for the treatment of Type 1 Diabetes: Discovery of 6-azaindole derivative GNF2133 YA Liu, Q Jin, Y Zou, Q Ding, S Yan, Z Wang, X Hao, B Nguyen, X Zhang, ... Journal of medicinal chemistry 63 (6), 2958-2973, 2020 | 59 | 2020 |
| A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome M DiDonato, AM Deacon, HE Klock, D McMullan, SA Lesley Journal of structural and functional genomics 5, 133-146, 2004 | 50 | 2004 |
| Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 Å resolution Q Xu, R Schwarzenbacher, S Sri Krishna, D McMullan, S Agarwalla, ... Proteins: Structure, Function, and Bioinformatics 64 (3), 808-813, 2006 | 43 | 2006 |
| Zinc Binding to the NH2-terminal Domain of the Wilson Disease Copper-transporting ATPase IMPLICATIONS FOR IN VIVO METAL ION-MEDIATED REGULATION OF ATPase ACTIVITY M DiDonato, J Zhang, L Que, B Sarkar Journal of Biological Chemistry 277 (16), 13409-13414, 2002 | 42 | 2002 |
| Crystal structure of a tandem cystathionine‐β‐synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution MD Miller, R Schwarzenbacher, F von Delft, P Abdubek, E Ambing, ... Proteins: Structure, Function, and Bioinformatics 57 (1), 213-217, 2004 | 39 | 2004 |
| Tuning a Protein‐Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation GH Pham, W Ou, B Bursulaya, M DiDonato, A Herath, Y Jin, X Hao, ... ChemBioChem 19 (8), 799-804, 2018 | 35 | 2018 |
| Structural, functional, and immunogenic insights on Cu, Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus AJ Pratt, M DiDonato, DS Shin, DE Cabelli, CK Bruns, CA Belzer, ... Journal of bacteriology 197 (24), 3834-3847, 2015 | 29 | 2015 |
| Handbook of metalloproteins ME Stroupe, M DiDonato, JA Tainer Messerschmidt, A, 941, 2001 | 22 | 2001 |
John TainerDirector of Structural Biology, Professor at MD Anderson Cancer Center & Lawrence Berkeley LabVerified email at mdanderson.org
