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Roy Ben-Shalom
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Opposing effects on NaV1. 2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures
R Ben-Shalom, CM Keeshen, KN Berrios, JY An, SJ Sanders, KJ Bender
Biological psychiatry 82 (3), 224-232, 2017
2502017
The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex
PWE Spratt, R Ben-Shalom, CM Keeshen, KJ Burke, RL Clarkson, ...
Neuron 103 (4), 673-685. e5, 2019
1722019
Paradoxical hyperexcitability from NaV1. 2 sodium channel loss in neocortical pyramidal cells
PWE Spratt, RPD Alexander, R Ben-Shalom, A Sahagun, H Kyoung, ...
Cell Reports 36 (5), 2021
662021
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons
JC Athilingam, R Ben-Shalom, CM Keeshen, VS Sohal, KJ Bender
Elife 6, e31991, 2017
492017
Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants
CH Thompson, R Ben-Shalom, KJ Bender, AL George Jr
Journal of General Physiology 152 (3), e201912442, 2020
362020
β-arrestin-dependent dopaminergic regulation of calcium channel activity in the axon initial segment
S Yang, R Ben-Shalom, M Ahn, AT Liptak, RM van Rijn, JL Whistler, ...
Cell reports 16 (6), 1518-1526, 2016
362016
Optimizing ion channel models using a parallel genetic algorithm on graphical processors
R Ben-Shalom, A Aviv, B Razon, A Korngreen
Journal of Neuroscience Methods 206 (2), 183-194, 2012
312012
Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice
DM Echevarria-Cooper, NA Hawkins, SN Misra, AM Huffman, T Thaxton, ...
Human molecular genetics 31 (17), 2964-2988, 2022
232022
Accelerating compartmental modeling on a graphical processing unit
R Ben-Shalom, G Liberman, A Korngreen
Frontiers in neuroinformatics 7, 4, 2013
222013
NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs
R Ben-Shalom, A Ladd, NS Artherya, C Cross, KG Kim, H Sanghevi, ...
Journal of neuroscience methods 366, 109400, 2022
16*2022
CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder
S Tamura, AD Nelson, PWE Spratt, H Kyoung, X Zhou, Z Li, J Zhao, ...
BioRxiv, 2022.03. 30.486483, 2022
142022
Inferring neuronal ionic conductances from membrane potentials using cnns
R Ben-Shalom, J Balewski, A Siththaranjan, V Baratham, H Kyoung, ...
bioRxiv, 727974, 2019
92019
Scaling and Benchmarking an Evolutionary Algorithm for constructing biophysical neuronal models
A Ladd, KG Kim, J Balewski, K Bouchard, R Ben-Shalom
Frontiers in Neuroinformatics 16, 882552, 2022
22022
The autism-associated gene Scn2a plays an essential role in synaptic stability and learning
PWE Spratt, R Ben-Shalom, CM Keeshen, KJ Burke Jr, RL Clarkson, ...
bioRxiv, 366781, 2018
22018
Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations
T Fenton, O Haouchine, E Hallam, E Smith, K Jackson, D Rahbarian, ...
bioRxiv, 2023.07. 24.550093, 2023
12023
Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy
S Quinn, N Zhang, TA Fenton, M Brusel, P Muruganandam, Y Peleg, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1870 (5), 167127, 2024
2024
Structural, biophysical, and neurophysiological effects of SCN2A mutations
SMA Wafa, G Yazdani, TA Fenton, CH Thompson, R Ben-Shalom, ...
Biophysical Journal 123 (3), 12a, 2024
2024
The SCN8A p.(Gly1625Arg) variant associated with developmental and epileptic encephalopathy causes complex biophysical changes and reduced neuronal firing
S Quinn, N Zhang, TA Fenton, M Brusel, P Muruganandam, Y Peleg, ...
bioRxiv, 2023
2023
Biophysical Mechanism of the Action Potential Initiation and Propagation in Cortical Pyramidal Neurons
R Ben-Shalom
Bar-Ilan University, 2014
2014
Using stochastic algorithms for constraining compartmental and markov channel models
R Ben-Shalom, A Korngreen
BMC Neuroscience 10 (Suppl 1), P35, 2009
2009
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Articles 1–20