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Richard G. Gardner
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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
RY Hampton, RG Gardner, J Rine
Molecular biology of the cell 7 (12), 2029-2044, 1996
6221996
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
NW Bays, RG Gardner, LP Seelig, CA Joazeiro, RY Hampton
Nature cell biology 3 (1), 24-29, 2001
5462001
Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p
RG Gardner, GM Swarbrick, NW Bays, SR Cronin, S Wilhovsky, L Seelig, ...
The Journal of cell biology 151 (1), 69-82, 2000
3492000
Degradation-mediated protein quality control in the nucleus
RG Gardner, ZW Nelson, DE Gottschling
Cell 120 (6), 803-815, 2005
3102005
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates
JC Rosenbaum, EK Fredrickson, ML Oeser, CM Garrett-Engele, ...
Molecular cell 41 (1), 93-106, 2011
1982011
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin
RG Gardner, ZW Nelson, DE Gottschling
Molecular and cellular biology 25 (14), 6123-6139, 2005
1792005
A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes
RG Gardner, RY Hampton
Journal of Biological Chemistry 274 (44), 31671-31678, 1999
1681999
Cotrafficking of SV2 and synaptotagmin at the synapse
J Yao, A Nowack, P Kensel-Hammes, RG Gardner, SM Bajjalieh
Journal of Neuroscience 30 (16), 5569-5578, 2010
1502010
In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation
RG Gardner, AG Shearer, RY Hampton
Molecular and cellular biology 21 (13), 4276-4291, 2001
1462001
HRD Gene Dependence of Endoplasmic Reticulum-associated Degradation
S Wilhovsky, R Gardner, R Hampton
Molecular Biology of the Cell 11 (5), 1697-1708, 2000
1272000
α-Arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling
AF O'Donnell, A Apffel, RG Gardner, MS Cyert
Molecular biology of the cell 21 (20), 3552-3566, 2010
1172010
Use of a modified Bacteroides-Prevotella shuttle vector to transfer a reconstructed beta-1, 4-D-endoglucanase gene into Bacteroides uniformis and Prevotella ruminicola B (1) 4
RG Gardner, JB Russell, DB Wilson, GR Wang, NB Shoemaker
Applied and environmental microbiology 62 (1), 196-202, 1996
1121996
Exposed hydrophobicity is a key determinant of nuclear quality control degradation
EK Fredrickson, JC Rosenbaum, MN Locke, TI Milac, RG Gardner
Molecular biology of the cell 22 (13), 2384-2395, 2011
1102011
A ‘distributed degron’allows regulated entry into the ER degradation pathway
RG Gardner, RY Hampton
The EMBO Journal 18 (21), 5994-6004, 1999
961999
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
R Gardner, S Cronin, B Leader, J Rine, R Hampton
Molecular Biology of the Cell 9 (9), 2611-2626, 1998
861998
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
EK Fredrickson, RG Gardner
Seminars in cell & developmental biology 23 (5), 530-537, 2012
702012
An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast
RG Gardner, H Shan, SPT Matsuda, RY Hampton
Journal of Biological Chemistry 276 (12), 8681-8694, 2001
602001
The Recruitment of the Saccharomyces cerevisiae Paf1 Complex to Active Genes Requires a Domain of Rtf1 That Directly Interacts with the Spt4-Spt5 Complex
MK Mayekar, RG Gardner, KM Arndt
Molecular and cellular biology 33 (16), 3259-3273, 2013
592013
Protein quality control degradation in the nucleus
C Enam, Y Geffen, T Ravid, RG Gardner
Annual Review of Biochemistry 87, 725-749, 2018
552018
Substrate recognition in nuclear protein quality control degradation is governed by exposed hydrophobicity that correlates with aggregation and insolubility
EK Fredrickson, PS Gallagher, SVC Candadai, RG Gardner
Journal of Biological Chemistry 288 (9), 6130-6139, 2013
542013
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