Raphael Kopan

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Eric H. SchroeterInstructor, Lakeview Technology AcademyVerified email at kusd.edu
Ma. Xenia G. IlaganWashington UniversityVerified email at wustl.edu
Alison GoateProfessor of Genetics & Genomic Sciences, Icahn School of Medicine at Mount SinaiVerified email at mssm.edu
Jim RayWashington University, Merck, Envoy Therapeutics, Takeda, MD AndersonVerified email at mdanderson.org
Jeff MummJohns Hopkins UniversityVerified email at jhmi.edu
Bart De Stroopergewoon hoogleraar KU Leuven en onderzoeksdirecteur VIBVerified email at cme.vib-kuleuven.be
Michael WolfeProfessor of Medicinal Chemistry, University of KansasVerified email at ku.edu
Taisuke TomitaProfessor at Graduate School of Pharmaceutical Sciences, The University of TokyoVerified email at mol.f.u-tokyo.ac.jp
Takeshi IwatsuboProfessor of Neuropathology, The University of TokyoVerified email at m.u-tokyo.ac.jp
Paul SaftigProfessor of BiochemistryVerified email at biochem.uni-kiel.de
Jeffrey NyeJohnson & Johnson Innovation, Janssen R&D, LLCVerified email at its.jnj.com
Marc VooijsProfessor of Radiation Oncology Maastricht UniversityVerified email at maastrichtuniversity.nl
Mustafa TurkozResearch FellowVerified email at stanford.edu
Kameswaran SurendranSanford researchVerified email at sanfordhealth.org
Chin-Tong OngTemasek Life Science LabVerified email at tll.org.sg
Mitsuru MorimotoRIKEN BDRVerified email at riken.jp
Brandon HadlandFred Hutchinson Cancer Research Center, University of WashingtonVerified email at fredhutch.org
Shuang ChenPfizerVerified email at pfizer.com
Fanxin LongProfessor of Medicine and Developmental Biology, Orthopaedic Surgery, Washington University in StVerified email at wustl.edu
Jeffrey H. MinerProf. of Medicine/Nephrology, Washington University School of Medicine in St. LouisVerified email at wustl.edu

Raphael Kopan

Cincinnati Children's Hospital Medical Center

Verified email at cchmc.org - Homepage

Developmental Biology


Title Sort by citations Sort by year Sort by title	Cited by Cited by	Year
The canonical Notch signaling pathway: unfolding the activation mechanism R Kopan, MXG Ilagan Cell 137 (2), 216-233, 2009	2999	2009
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ... Nature 398 (6727), 518-522, 1999	2450	1999
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain EH Schroeter, JA Kisslinger, R Kopan Nature 393 (6683), 382-386, 1998	1791	1998
Signalling downstream of activated mammalian Notch S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel Nature 377 (6547), 355-358, 1995	1635	1995
Notch signaling: from the outside in JS Mumm, R Kopan Developmental biology 228 (2), 151-165, 2000	1161	2000
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1 JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ... Molecular cell 5 (2), 197-206, 2000	978	2000
NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration D Selkoe, R Kopan Annual review of neuroscience 26 (1), 565-597, 2003	769	2003
γ-Secretase: proteasome of the membrane? R Kopan, MXG Ilagan Nature reviews Molecular cell biology 5 (6), 499-504, 2004	646	2004
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ... Nature immunology 13 (2), 144-151, 2012	603	2012
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain R Kopan, EH Schroeter, H Weintraub, JS Nye Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996	571	1996
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development F Costantini, R Kopan Developmental cell 18 (5), 698-712, 2010	563	2010
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD R Kopan, JS Nye, H Weintraub Development 120 (9), 2385-2396, 1994	551	1994
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ... Nature medicine 14 (3), 306-314, 2008	543	2008
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro DJ McCance, R Kopan, E Fuchs, LA Laimins Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988	481	1988
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher, J Shen Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010	458	2010
Intramembrane proteolysis: theme and variations MS Wolfe, R Kopan Science 305 (5687), 1119-1123, 2004	415	2004
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. A Stoler, R Kopan, M Duvic, E Fuchs The Journal of cell biology 107 (2), 427-446, 1988	400	1988
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. R Kopan, G Traska, E Fuchs The Journal of cell biology 105 (1), 427-440, 1987	393	1987
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ... Nature 405 (6789), 966-970, 2000	388	2000
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ... Cell 115 (2), 163-175, 2003	387	2003

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