| Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome L Macia, J Tan, AT Vieira, K Leach, D Stanley, S Luong, M Maruya, ... Nature communications 6 (1), 6734, 2015 | 1272 | 2015 |
| Allosteric modulation of G protein-coupled receptors LT May, K Leach, PM Sexton, A Christopoulos Annu. Rev. Pharmacol. Toxicol. 47, 1-51, 2007 | 826 | 2007 |
| THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British journal of pharmacology 176, S21-S141, 2019 | 792 | 2019 |
| The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British journal of pharmacology 178, S27-S156, 2021 | 494 | 2021 |
| Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology K Leach, PM Sexton, A Christopoulos Trends in pharmacological sciences 28 (8), 382-389, 2007 | 396 | 2007 |
| Crystal structures of the M1 and M4 muscarinic acetylcholine receptors DM Thal, B Sun, D Feng, V Nawaratne, K Leach, CC Felder, MG Bures, ... Nature 531 (7594), 335-340, 2016 | 360 | 2016 |
| The concise guide to pharmacology 2017/18: overview SPH Alexander, E Kelly, NV Marrion, JA Peters, E Faccenda, SD Harding, ... British journal of pharmacology 174, S1-S16, 2017 | 314 | 2017 |
| Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor AE Davey, K Leach, C Valant, AD Conigrave, PM Sexton, A Christopoulos Endocrinology 153 (3), 1232-1241, 2012 | 183 | 2012 |
| Molecular mechanisms of action and in vivo validation of an M 4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties K Leach, RE Loiacono, CC Felder, DL McKinzie, A Mogg, DB Shaw, ... Neuropsychopharmacology 35 (4), 855-869, 2010 | 173 | 2010 |
| Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptor E Khajehali, DT Malone, M Glass, PM Sexton, A Christopoulos, K Leach Molecular pharmacology 88 (2), 368-379, 2015 | 159 | 2015 |
| The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, AA Mathie, ... British journal of pharmacology 180, S23-S144, 2023 | 150 | 2023 |
| New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a … V Nawaratne, K Leach, N Suratman, RE Loiacono, CC Felder, ... Molecular pharmacology 74 (4), 1119-1131, 2008 | 136 | 2008 |
| Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor K Leach, KJ Gregory, I Kufareva, E Khajehali, AE Cook, R Abagyan, ... Cell research 26 (5), 574-592, 2016 | 118 | 2016 |
| International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function K Leach, FM Hannan, TM Josephs, AN Keller, TC Møller, DT Ward, ... Pharmacological Reviews 72 (3), 558-604, 2020 | 92 | 2020 |
| Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics AE Cook, SN Mistry, KJ Gregory, SGB Furness, PM Sexton, PJ Scammells, ... British journal of pharmacology 172 (1), 185-200, 2015 | 92 | 2015 |
| Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators K Leach, A Wen, AE Cook, PM Sexton, AD Conigrave, A Christopoulos Endocrinology 154 (3), 1105-1116, 2013 | 88 | 2013 |
| Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor IDENTIFICATION OF LIGAND-SPECIFIC AND GLOBAL ACTIVATION MECHANISMS V Nawaratne, K Leach, CC Felder, PM Sexton, A Christopoulos Journal of Biological Chemistry 285 (25), 19012-19021, 2010 | 84 | 2010 |
| Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor K Leach, A Wen, AE Davey, PM Sexton, AD Conigrave, A Christopoulos Endocrinology 153 (9), 4304-4316, 2012 | 83 | 2012 |
| Structure and dynamics of the CGRP receptor in apo and peptide-bound forms TM Josephs, MJ Belousoff, YL Liang, SJ Piper, J Cao, DJ Garama, ... Science 372 (6538), eabf7258, 2021 | 71 | 2021 |
| Impact of species variability and ‘probe‐dependence’on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor S Suratman, K Leach, PM Sexton, CC Felder, RE Loiacono, ... British journal of pharmacology 162 (7), 1659-1670, 2011 | 65 | 2011 |
