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Luke Jen O'Connor
Luke Jen O'Connor
Harvard Medical School
Verified email at broadinstitute.org - Homepage
Title
Cited by
Cited by
Year
Distinguishing genetic correlation from causation across 52 diseases and complex traits
LJ O’Connor, AL Price
Nature genetics 50 (12), 1728-1734, 2018
3182018
Distinguishing genetic correlation from causation across 52 diseases and complex traits
LJ O’Connor, AL Price
Nature genetics 50 (12), 1728-1734, 2018
3082018
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
A Tin, J Marten, VL Halperin Kuhns, Y Li, M Wuttke, H Kirsten, KB Sieber, ...
Nature genetics 51 (10), 1459-1474, 2019
2822019
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank
Z Zhu, Y Guo, H Shi, CL Liu, RA Panganiban, W Chung, LJ O'Connor, ...
Journal of Allergy and Clinical Immunology 145 (2), 537-549, 2020
2642020
Quantifying genetic effects on disease mediated by assayed gene expression levels
DW Yao, LJ O’connor, AL Price, A Gusev
Nature genetics 52 (6), 626-633, 2020
2192020
Functionally informed fine-mapping and polygenic localization of complex trait heritability
O Weissbrod, F Hormozdiari, C Benner, R Cui, J Ulirsch, S Gazal, ...
Nature genetics 52 (12), 1355-1363, 2020
2072020
Extreme polygenicity of complex traits is explained by negative selection
LJ O'Connor, AP Schoech, F Hormozdiari, S Gazal, N Patterson, AL Price
The American Journal of Human Genetics 105 (3), 456-476, 2019
2022019
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
F Hormozdiari, S Gazal, B Van De Geijn, HK Finucane, CJT Ju, PR Loh, ...
Nature genetics 50 (7), 1041-1047, 2018
1562018
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
AP Schoech, DM Jordan, PR Loh, S Gazal, LJ O’Connor, DJ Balick, ...
Nature communications 10 (1), 790, 2019
1042019
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
S Gazal, O Weissbrod, F Hormozdiari, KK Dey, J Nasser, KA Jagadeesh, ...
Nature genetics 54 (6), 827-836, 2022
762022
Functional architectures of local and distal regulation of gene expression in multiple human tissues
X Liu, HK Finucane, A Gusev, G Bhatia, S Gazal, L O’Connor, ...
The American Journal of Human Genetics 100 (4), 605-616, 2017
762017
Polygenic architecture of rare coding variation across 394,783 exomes
DJ Weiner, A Nadig, KA Jagadeesh, KK Dey, BM Neale, EB Robinson, ...
Nature 614 (7948), 492-499, 2023
602023
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
YA Reshef, HK Finucane, DR Kelley, A Gusev, D Kotliar, JC Ulirsch, ...
Nature genetics 50 (10), 1483-1493, 2018
592018
Genes with high network connectivity are enriched for disease heritability
SS Kim, C Dai, F Hormozdiari, B van de Geijn, S Gazal, Y Park, ...
The American Journal of Human Genetics 104 (5), 896-913, 2019
532019
The distribution of common-variant effect sizes
LJ O’Connor
Nature genetics 53 (8), 1243-1249, 2021
482021
Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
AP Schoech, D Jordan, PR Loh, S Gazal, L O’Connor, DJ Balick, ...
BioRxiv, 188086, 2017
222017
German Chronic Kidney Disease Study; Lifelines Cohort Study; VA Million Veteran Program. Target genes, variants, tissues and transcriptional pathways influencing human serum …
A Tin, J Marten, VL Halperin Kuhns, Y Li, M Wuttke, H Kirsten, KB Sieber, ...
Nat Genet 51 (1459-1474), 31578528, 2019
192019
Significance testing for small annotations in stratified LD-Score regression
KC Tashman, R Cui, LJ O’Connor, BM Neale, HK Finucane
medRxiv, 2021.03. 13.21249938, 2021
152021
Functional disease architectures reveal unique biological role of transposable elements
F Hormozdiari, B van de Geijn, J Nasser, O Weissbrod, S Gazal, CJT Ju, ...
Nature communications 10 (1), 4054, 2019
142019
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p
DJ Weiner, E Ling, S Erdin, DJC Tai, R Yadav, J Grove, JM Fu, A Nadig, ...
Nature genetics 54 (11), 1630-1639, 2022
132022
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