Judith Maxwell Silverman
Judith Maxwell Silverman
Brain Research Centre UBC
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An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages
JM Silverman, J Clos, CC de'Oliveira, O Shirvani, Y Fang, C Wang, ...
Journal of cell science 123 (6), 842-852, 2010
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms
LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ...
Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014
Proteomic analysis of the secretome of Leishmania donovani
JM Silverman, SK Chan, DP Robinson, DM Dwyer, D Nandan, LJ Foster, ...
Genome biology 9, 1-21, 2008
Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells
JM Silverman, J Clos, E Horakova, AY Wang, M Wiesgigl, I Kelly, MA Lynn, ...
The Journal of Immunology 185 (9), 5011-5022, 2010
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles
F Martínez-Gutierrez, EP Thi, JM Silverman, CC de Oliveira, SL Svensson, ...
Nanomedicine: Nanotechnology, Biology and Medicine 8 (3), 328-336, 2012
Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes
JM Silverman, NE Reiner
Cellular microbiology 13 (1), 1-9, 2011
Leishmania Exosomes Deliver Preemptive Strikes to Create an Environment Permissive for Early Infection
JM Silverman, NE Reiner
Frontiers in cellular and infection microbiology 1, 26, 2012
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1
JM Silverman, D Christy, CC Shyu, KM Moon, S Fernando, Z Gidden, ...
Journal of Biological Chemistry 294 (10), 3744-3759, 2019
Disease mechanisms in ALS: misfolded SOD1 transferred through exosome-dependent and exosome-independent pathways
JM Silverman, SM Fernando, LI Grad, AF Hill, BJ Turner, JJ Yerbury, ...
Cellular and molecular neurobiology 36, 377-381, 2016
Secreted virulence factors and immune evasion in visceral leishmaniasis
U Lambertz, JM Silverman, D Nandan, WR McMaster, J Clos, LJ Foster, ...
Journal of leukocyte biology 91 (6), 887-899, 2012
Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase
D Nandan, C Camargo de Oliveira, A Moeenrezakhanlou, M Lopez, ...
The Journal of Immunology 188 (1), 367-378, 2012
Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit
WC Guest, JM Silverman, E Pokrishevsky, MA O'Neill, LI Grad, ...
Journal of Toxicology and Environmental Health, Part A 74 (22-24), 1433-1459, 2011
Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding
LI Grad, E Pokrishevsky, JM Silverman, NR Cashman
Prion 8 (5), 331-335, 2014
Identification of leishmania fructose-1, 6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1
D Nandan, T Tran, E Trinh, JM Silverman, M Lopez
Biochemical and biophysical research communications 364 (3), 601-607, 2007
A rationally designed humanized antibody selective for amyloid beta oligomers in Alzheimer’s disease
E Gibbs, JM Silverman, B Zhao, X Peng, J Wang, CL Wellington, ...
Scientific reports 9 (1), 9870, 2019
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
J Robert, EB Button, EM Martin, L McAlary, Z Gidden, M Gilmour, G Boyce, ...
Molecular neurodegeneration 15, 1-21, 2020
A rational structured epitope defines a distinct subclass of toxic amyloid-beta oligomers
JM Silverman, E Gibbs, X Peng, KM Martens, C Balducci, J Wang, ...
ACS Chemical Neuroscience 9 (7), 1591-1606, 2018
P4‐299: A Computational Method to Predict Disease‐Specific Epitopes in Aβ, and its Application to Oligomer‐Selective Antibodies for Alzheimer’S Immunotherapy
SS Plotkin, X Peng, JM Silverman, NR Cashman
Alzheimer's & Dementia 12, P1148-P1148, 2016
Targeting of toxic amyloid-beta oligomer species by monoclonal antibody PMN310: precision drug design for Alzheimer’s disease
J Kaplan, JM Silverman, E Gibbs, J Wang, X Peng, SS Plotkin, ...
Alzheimer's & Dementia 13 (7), P592, 2017
A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria
X Peng, E Gibbs, JM Silverman, NR Cashman, SS Plotkin
Statistical Methods in Medical Research 30 (6), 1502-1522, 2021
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