Raphael I. Benhamou
Raphael I. Benhamou
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Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders
HS Haniff, Y Tong, X Liu, JL Chen, BM Suresh, RJ Andrews, JM Peterson, ...
ACS Central Science 6 (10), 1713-1721, 2020
Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm
D Kim, Y Liu, RI Benhamou, H Sanchez, Á Simón-Soro, Y Li, G Hwang, ...
The ISME journal 12 (6), 1427-1442, 2018
Real-time imaging of the azole class of antifungal drugs in live Candida cells
RI Benhamou, M Bibi, KB Steinbuch, H Engel, M Levin, Y Roichman, ...
ACS chemical biology 12 (7), 1769-1777, 2017
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus
D Matzov, Z Eyal, RI Benhamou, M Shalev-Benami, Y Halfon, M Krupkin, ...
Nucleic acids research 45 (17), 10284-10292, 2017
Reprogramming of protein-targeted small-molecule medicines to RNA by ribonuclease recruitment
P Zhang, X Liu, D Abegg, T Tanaka, Y Tong, RI Benhamou, J Baisden, ...
Journal of the American Chemical Society 143 (33), 13044-13055, 2021
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles
R Elias, RI Benhamou, QZ Jaber, O Dorot, SL Zada, K Oved, E Pichinuk, ...
European journal of medicinal chemistry 179, 779-790, 2019
Di‐N‐Methylation of Anti‐Gram‐Positive Aminoglycoside‐Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram …
RI Benhamou, P Shaul, IM Herzog, M Fridman
Angewandte Chemie 127 (46), 13821-13825, 2015
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
JA Bush, H Aikawa, R Fuerst, Y Li, A Ursu, SM Meyer, RI Benhamou, ...
Science translational medicine 13 (617), eabd5991, 2021
Tobramycin and nebramine as pseudo‐oligosaccharide scaffolds for the development of antimicrobial cationic amphiphiles
Y Berkov‐Zrihen, IM Herzog, RI Benhamou, M Feldman, KB Steinbuch, ...
Chemistry–A European Journal 21 (11), 4340-4349, 2015
Localizing Antifungal Drugs to the Correct Organelle can Markedly Enhance their Efficacy
RI Benhamou, M Bibi, J Berman, M Fridman
Angewandte Chemie, 2018
Increased degree of unsaturation in the lipid of antifungal cationic amphiphiles facilitates selective fungal cell disruption
KB Steinbuch, RI Benhamou, L Levin, R Stein, M Fridman
ACS Infectious Diseases 4 (5), 825-836, 2018
Fluorescent tracking of the endoplasmic reticulum in live pathogenic fungal cells
RI Benhamou, QZ Jaber, IM Herzog, Y Roichman, M Fridman
ACS Chemical Biology 13 (12), 3325-3332, 2018
Programming inactive RNA-binding small molecules into bioactive degraders
Y Tong, Y Lee, X Liu, JL Childs-Disney, BM Suresh, RI Benhamou, ...
Nature 618 (7963), 169-179, 2023
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor
RI Benhamou, BM Suresh, Y Tong, WG Cochrane, V Cavett, ...
Proceedings of the National Academy of Sciences 119 (6), e2114971119, 2022
A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex
AJ Angelbello, RI Benhamou, SG Rzuczek, S Choudhary, Z Tang, ...
Cell chemical biology 28 (1), 34-45. e6, 2021
Cationic amphiphiles induce macromolecule denaturation and organelle decomposition in pathogenic yeast
QZ Jaber, RI Benhamou, IM Herzog, B Ben Baruch, M Fridman
Angewandte Chemie 130 (50), 16629-16633, 2018
Antifungal Imidazole‐Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity
RI Benhamou, KB Steinbuch, M Fridman
Chemistry–A European Journal 22 (32), 11148-11151, 2016
Structure-specific cleavage of an RNA repeat expansion with a dimeric small molecule is advantageous over sequence-specific recognition by an oligonucleotide
RI Benhamou, AJ Angelbello, RJ Andrews, ET Wang, WN Moss, ...
ACS chemical biology 15 (2), 485-493, 2020
Tuning the Effects of Bacterial Membrane Permeability through Photo‐Isomerization of Antimicrobial Cationic Amphiphiles
J Salta, RI Benhamou, IM Herzog, M Fridman
Chemistry a European Journal 23 (52), 12724-12728, 2017
Combining colistin and fluconazole synergistically increases fungal membrane permeability and antifungal cidality
M Bibi, S Murphy, RI Benhamou, A Rosenberg, A Ulman, T Bicanic, ...
ACS Infectious Diseases 7 (2), 377-389, 2021
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