Willem-Jan Keune
Willem-Jan Keune
Verified email at nki.nl
Title
Cited by
Cited by
Year
Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
BJM Braakhuis, PJF Snijders, WJH Keune, CJLM Meijer, ...
Journal of the national cancer institute 96 (13), 998-1006, 2004
4572004
Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta
DR Jones, Y Bultsma, WJ Keune, JR Halstead, D Elouarrat, S Mohammed, ...
Molecular cell 23 (5), 685-695, 2006
1842006
PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα
Y Bultsma, WJ Keune, N Divecha
Biochemical Journal 430 (2), 223-235, 2010
732010
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
WJ Keune, J Hausmann, R Bolier, D Tolenaars, A Kremer, T Heidebrecht, ...
Nature communications 7 (1), 1-10, 2016
582016
Rac controls PIP5K localisation and PtdIns (4, 5) P2 synthesis, which modulates vinculin localisation and neurite dynamics
JR Halstead, NE Savaskan, I Van Den Bout, F Van Horck, ...
Journal of cell science 123 (20), 3535-3546, 2010
502010
Phosphoinositide signalling in the nucleus
W Keune, Y Bultsma, L Sommer, D Jones, N Divecha
Advances in enzyme regulation 51 (1), 91, 2011
432011
PtdIns5P is an oxidative stress‐induced second messenger that regulates PKB activation
DR Jones, R Foulger, WJ Keune, Y Bultsma, N Divecha
The FASEB Journal 27 (4), 1644-1656, 2013
402013
PIP4K and the role of nuclear phosphoinositides in tumour suppression
R Fiume, Y Stijf-Bultsma, ZH Shah, WJ Keune, DR Jones, JG Jude, ...
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2015
352015
Nuclear phosphoinositides: location, regulation and function
R Fiume, WJ Keune, I Faenza, Y Bultsma, G Ramazzotti, DR Jones, ...
Phosphoinositides II: The Diverse Biological Functions, 335-361, 2012
352012
Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress
WJ Keune, DR Jones, Y Bultsma, L Sommer, XZ Zhou, KP Lu, N Divecha
Science signaling 5 (252), ra86-ra86, 2012
342012
PtdIns5P and Pin1 in oxidative stress signaling
WJ Keune, DR Jones, N Divecha
Advances in biological regulation 53 (2), 179-189, 2013
312013
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: a role for PIP4K2B in the regulation of E-cadherin expression
WJ Keune, AH Sims, DR Jones, Y Bultsma, JT Lynch, K Jirström, ...
Cancer research 73 (23), 6913-6925, 2013
282013
The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress
LA Mans, LQ Cano, J van Pelt, P Giardoglou, WJ Keune, APG Haramis
Scientific reports 7 (1), 1-10, 2017
222017
The hexosamine biosynthesis pathway and O‐Glc NA cylation maintain insulin‐stimulated PI 3K‐PKB phosphorylation and tumour cell growth after short‐term glucose deprivation
DR Jones, WJ Keune, KE Anderson, LR Stephens, PT Hawkins, ...
The FEBS journal 281 (16), 3591-3608, 2014
222014
Structure–activity relationships of small molecule autotaxin inhibitors with a discrete binding mode
LM Miller, WJ Keune, D Castagna, LC Young, EL Duffy, F Potjewyd, ...
Journal of medicinal chemistry 60 (2), 722-748, 2017
202017
Rational design of autotaxin inhibitors by structural evolution of endogenous modulators
WJ Keune, F Potjewyd, T Heidebrecht, F Salgado-Polo, SJF Macdonald, ...
Journal of medicinal chemistry 60 (5), 2006-2017, 2017
172017
Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin
J Hausmann, WJ Keune, ALH Ederveen, L van Zeijl, RP Joosten, ...
Journal of structural biology 195 (2), 199-206, 2016
132016
Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns (4, 5) P2 synthesis in response to …
I van den Bout, DR Jones, ZH Shah, JR Halstead, WJ Keune, ...
Biochemical Journal 455 (3), 347-358, 2013
112013
Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency
F Salgado-Polo, A Fish, MT Matsoukas, T Heidebrecht, WJ Keune, ...
Journal of Biological Chemistry 293 (37), 14312-14327, 2018
102018
Methods for the Determination of the Mass of Nuclear PtdIns4P, PtdIns5P, and PtdIns(4,5)P 2
DR Jones, Y Bultsma, WJ Keune, N Divecha
Lipid Signaling Protocols, 1-14, 2009
92009
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Articles 1–20