עקוב אחר
Florian Nigsch
Florian Nigsch
Director Data Science, Novartis Institutes for BioMedical Research
כתובת אימייל מאומתת בדומיין flo.nigsch.com
כותרת
צוטט על ידי
צוטט על ידי
שנה
Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information‏
I Sushko, S Novotarskyi, R Körner, AK Pandey, M Rupp, W Teetz, ...‏
Journal of computer-aided molecular design 25, 533-554, 2011‏
5982011
Cell types of the human retina and its organoids at single-cell resolution‏
CS Cowan, M Renner, M De Gennaro, B Gross-Scherf, D Goldblum, ...‏
Cell 182 (6), 1623-1640. e34, 2020‏
3852020
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size‏
L Planas-Paz, V Orsini, L Boulter, D Calabrese, M Pikiolek, F Nigsch, ...‏
Nature cell biology 18 (5), 467-479, 2016‏
2602016
Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization‏
F Nigsch, A Bender, B van Buuren, J Tissen, E Nigsch, JBO Mitchell‏
Journal of chemical information and modeling 46 (6), 2412-2422, 2006‏
2372006
Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P‏
LD Hughes, DS Palmer, F Nigsch, JBO Mitchell‏
Journal of chemical information and modeling 48 (1), 220-232, 2008‏
2252008
YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury‏
L Planas-Paz, T Sun, M Pikiolek, NR Cochran, S Bergling, V Orsini, ...‏
Cell stem cell 25 (1), 39-53. e10, 2019‏
1742019
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions‏
D Hoepfner, SB Helliwell, H Sadlish, S Schuierer, I Filipuzzi, S Brachat, ...‏
Microbiological research 169 (2-3), 107-120, 2014‏
1642014
Rethinking molecular similarity: comparing compounds on the basis of biological activity‏
PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ...‏
ACS chemical biology 7 (8), 1399-1409, 2012‏
1632012
Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics‏
F Nigsch, A Bender, JL Jenkins, JBO Mitchell‏
Journal of chemical information and modeling 48 (12), 2313-2325, 2008‏
1322008
Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy‏
C Potting, C Crochemore, F Moretti, F Nigsch, I Schmidt, C Manneville, ...‏
Proceedings of the National Academy of Sciences 115 (2), E180-E189, 2018‏
962018
Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia‏
C Dafflon, VJ Craig, H Mereau, J Gräsel, B Schacher Engstler, G Hoffman, ...‏
Leukemia 31 (6), 1269-1277, 2017‏
962017
Total synthesis of (+)-crocacin D‏
LC Dias, LG de Oliveira, JD Vilcachagua, F Nigsch‏
The Journal of Organic Chemistry 70 (6), 2225-2234, 2005‏
852005
Computational toxicology: an overview of the sources of data and of modelling methods‏
F Nigsch, NJM Macaluso, JBO Mitchell, D Zmuidinavicius‏
Expert Opinion on Drug Metabolism & Toxicology 5 (1), 1-14, 2009‏
832009
Predicting the mechanism of phospholipidosis‏
R Lowe, HY Mussa, F Nigsch, RC Glen, JBO Mitchell‏
Journal of cheminformatics 4, 1-9, 2012‏
732012
A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi‏
A Voorberg-van der Wel, G Roma, DK Gupta, S Schuierer, F Nigsch, ...‏
Elife 6, e29605, 2017‏
692017
Recent trends and observations in the design of high-quality screening collections‏
S Renner, M Popov, A Schuffenhauer, HJ Roth, W Breitenstein, ...‏
Future medicinal chemistry 3 (6), 751-766, 2011‏
642011
Evidence-based and quantitative prioritization of tool compounds in phenotypic drug discovery‏
Y Wang, A Cornett, FJ King, Y Mao, F Nigsch, CG Paris, G McAllister, ...‏
Cell chemical biology 23 (7), 862-874, 2016‏
602016
Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis‏
ZY Wang, A Keogh, A Waldt, R Cuttat, M Neri, S Zhu, S Schuierer, ...‏
Scientific reports 11 (1), 19396, 2021‏
592021
Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy‏
NL Bertschi, A Voorberg-Van der Wel, AM Zeeman, S Schuierer, F Nigsch, ...‏
Elife 7, e41081, 2018‏
452018
Analysis of iterative screening with stepwise compound selection based on Novartis in-house HTS data‏
S Paricharak, AP IJzerman, A Bender, F Nigsch‏
ACS chemical biology 11 (5), 1255-1264, 2016‏
452016
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מאמרים 1–20