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Ouathek Ouerfelli
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Year
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor–mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
MN Balak, Y Gong, GJ Riely, R Somwar, AR Li, MF Zakowski, A Chiang, ...
Clinical cancer research 12 (21), 6494-6501, 2006
9722006
ARN-509: a novel antiandrogen for prostate cancer treatment
NJ Clegg, J Wongvipat, JD Joseph, C Tran, S Ouk, A Dilhas, Y Chen, ...
Cancer research 72 (6), 1494-1503, 2012
7632012
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90
C Schneider, L Sepp-Lorenzino, E Nimmesgern, O Ouerfelli, ...
Proceedings of the National Academy of Sciences 93 (25), 14536-14541, 1996
5221996
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
L Regales, Y Gong, R Shen, E de Stanchina, I Vivanco, A Goel, ...
The Journal of clinical investigation 119 (10), 3000-3010, 2009
4742009
Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’protein
N Abdul-Manan, B Aghazadeh, GA Liu, A Majumdar, O Ouerfelli, ...
Nature 399 (6734), 379-383, 1999
4301999
Loss of BAP1 function leads to EZH2-dependent transformation
LM LaFave, W Béguelin, R Koche, M Teater, B Spitzer, A Chramiec, ...
Nature medicine 21 (11), 1344-1349, 2015
3552015
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation
JR Peterson, LC Bickford, D Morgan, AS Kim, O Ouerfelli, MW Kirschner, ...
Nature structural & molecular biology 11 (8), 747-755, 2004
2172004
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans
S Marubayashi, P Koppikar, T Taldone, O Abdel-Wahab, N West, ...
The Journal of clinical investigation 120 (10), 3578-3593, 2010
2112010
Sequence characteristics of functional siRNAs
B Jagla, N Aulner, PD Kelly, DA Song, A Volchuk, A Zatorski, D Shum, ...
Rna 11 (6), 864-872, 2005
1952005
Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates
G Ragupathi, F Koide, PO Livingston, YS Cho, A Endo, Q Wan, ...
Journal of the American Chemical Society 128 (8), 2715-2725, 2006
1942006
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
E Petrova, J Rios-Esteves, O Ouerfelli, JF Glickman, MD Resh
Nature chemical biology 9 (4), 247-249, 2013
1742013
Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer
PJ Sabbatini, G Ragupathi, C Hood, CA Aghajanian, M Juretzka, ...
Clinical cancer research 13 (14), 4170-4177, 2007
1632007
The polycomb repressor complex 1 drives double-negative prostate cancer metastasis by coordinating stemness and immune suppression
W Su, HH Han, Y Wang, B Zhang, B Zhou, Y Cheng, A Rumandla, ...
Cancer cell 36 (2), 139-155. e10, 2019
1602019
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines
R Somwar, H Erdjument-Bromage, E Larsson, D Shum, WW Lockwood, ...
Proceedings of the National Academy of Sciences 108 (39), 16375-16380, 2011
1562011
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase
LPS de Carvalho, H Zhao, CE Dickinson, NM Arango, CD Lima, ...
Chemistry & biology 17 (4), 323-332, 2010
1202010
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
B Gold, M Pingle, SJ Brickner, N Shah, J Roberts, M Rundell, WC Bracken, ...
Proceedings of the National Academy of Sciences 109 (40), 16004-16011, 2012
1192012
From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine
J Zhu, Q Wan, D Lee, G Yang, MK Spassova, O Ouerfelli, G Ragupathi, ...
Journal of the American Chemical Society 131 (26), 9298-9303, 2009
1182009
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells
J Vaubourgeix, G Lin, N Dhar, N Chenouard, X Jiang, H Botella, T Lupoli, ...
Cell host & microbe 17 (2), 178-190, 2015
1002015
CSF1/CSF1R signaling inhibitor pexidartinib (PLX3397) reprograms tumor-associated macrophages and stimulates T-cell infiltration in the sarcoma microenvironment
T Fujiwara, MA Yakoub, A Chandler, AB Christ, G Yang, O Ouerfelli, ...
Molecular cancer therapeutics 20 (8), 1388-1399, 2021
972021
CRISPR-Cas III-A Csm6 CARF domain is a ring nuclease triggering stepwise cA4 cleavage with ApA> p formation terminating RNase activity
N Jia, R Jones, G Yang, O Ouerfelli, DJ Patel
Molecular cell 75 (5), 944-956. e6, 2019
912019
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