Alexei Kisselev
Alexei Kisselev
Associate Professor of Drug Discovery and Development, Auburn University
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Proteasome inhibitors: from research tools to drug candidates
AF Kisselev, AL Goldberg
Chemistry & biology 8 (8), 739-758, 2001
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
R Groisman, J Polanowska, I Kuraoka, J Sawada, M Saijo, R Drapkin, ...
Cell 113 (3), 357-367, 2003
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes: implications for understanding the degradative mechanism and antigen presentation
AF Kisselev, TN Akopian, KM Woo, AL Goldberg
Journal of Biological Chemistry 274 (6), 3363-3371, 1999
Proteasome inhibitors: an expanding army attacking a unique target
AF Kisselev, WA van der Linden, HS Overkleeft
Chemistry & biology 19 (1), 99-115, 2012
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide …
HT Kim, KP Kim, F Lledias, AF Kisselev, KM Scaglione, D Skowyra, ...
Journal of biological chemistry 282 (24), 17375-17386, 2007
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
P Cascio, C Hilton, AF Kisselev, KL Rock, AL Goldberg
The EMBO journal 20 (10), 2357-2366, 2001
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
AF Kisselev, A Callard, AL Goldberg
Journal of Biological Chemistry 281 (13), 8582-8590, 2006
Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown
AF Kisselev, TN Akopian, V Castillo, AL Goldberg
Molecular cell 4 (3), 395-402, 1999
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates
AF Kisselev, AL Goldberg
Methods in enzymology 398, 364-378, 2005
Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes
AF Kisselev, TN Akopian, AL Goldberg
Journal of Biological Chemistry 273 (4), 1982-1989, 1998
CSA-dependent degradation of CSB by the ubiquitin–proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
R Groisman, I Kuraoka, O Chevallier, N Gaye, T Magnaldo, K Tanaka, ...
Genes & development 20 (11), 1429-1434, 2006
Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum
TN Akopian, AF Kisselev, AL Goldberg
Journal of Biological Chemistry 272 (3), 1791-1798, 1997
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
AF Kisselev, M Garcia-Calvo, HS Overkleeft, E Peterson, MW Pennington, ...
Journal of Biological Chemistry 278 (38), 35869-35877, 2003
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes: evidence for peptide-induced channel opening …
AF Kisselev, D Kaganovich, AL Goldberg
Journal of Biological Chemistry 277 (25), 22260-22270, 2002
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits
BM Kessler, D Tortorella, M Altun, AF Kisselev, E Fiebiger, BG Hekking, ...
Chemistry & biology 8 (9), 913-929, 2001
New insights into the mechanisms and importance of the proteasome in intracellular protein degradation.
AL Goldberg, TN Akopian, AF Kisselev, DH Lee, M Rohrwild
Biological chemistry 378 (3-4), 131-140, 1997
Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites
M Britton, MM Lucas, SL Downey, M Screen, AA Pletnev, M Verdoes, ...
Chemistry & biology 16 (12), 1278-1289, 2009
Why does threonine, and not serine, function as the active site nucleophile in proteasomes?
AF Kisselev, Z Songyang, AL Goldberg
Journal of Biological Chemistry 275 (20), 14831-14837, 2000
Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA
TC Albershardt, BL Salerni, RS Soderquist, DJP Bates, AA Pletnev, ...
Journal of Biological Chemistry 286 (28), 24882-24895, 2011
Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib
AC Mirabella, AA Pletnev, SL Downey, BI Florea, TB Shabaneh, M Britton, ...
Chemistry & biology 18 (5), 608-618, 2011
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