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Steven Fletcher
Steven Fletcher
Associate Professor of Chemistry at the University of Maryland
Verified email at rx.umaryland.edu
Title
Cited by
Cited by
Year
The Mitsunobu reaction in the 21 st century
S Fletcher
Organic Chemistry Frontiers 2 (6), 739-752, 2015
2972015
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson
Biochemical pharmacology 79 (10), 1398-1409, 2010
2232010
Targeting protein–protein interactions by rational design: mimicry of protein surfaces
S Fletcher, AD Hamilton
Journal of the Royal Society Interface 3 (7), 215-233, 2006
1992006
Protein surface recognition and proteomimetics: mimics of protein surface structure and function
S Fletcher, AD Hamilton
Current opinion in chemical biology 9 (6), 632-638, 2005
1752005
Small-molecule inhibitors of the Myc oncoprotein
S Fletcher, EV Prochownik
Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (5), 525-543, 2015
1742015
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain
P Mistry, MHW Laird, RS Schwarz, S Greene, T Dyson, GA Snyder, ...
Proceedings of the National Academy of Sciences 112 (17), 5455-5460, 2015
1532015
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
S Fletcher, J Turkson, PT Gunning
ChemMedChem 3 (8), 1159, 2008
1402008
The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
C Peddaboina, D Jupiter, S Fletcher, JL Yap, A Rai, RP Tobin, W Jiang, ...
BMC cancer 12, 1-12, 2012
1342012
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
1312009
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009
1212009
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
1202012
Perturbation of the c-Myc–Max protein–protein interaction via synthetic α-helix mimetics
KY Jung, H Wang, P Teriete, JL Yap, L Chen, ME Lanning, A Hu, ...
Journal of medicinal chemistry 58 (7), 3002-3024, 2015
1062015
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein …
X Cao, JL Yap, MK Newell-Rogers, C Peddaboina, W Jiang, ...
Molecular cancer 12, 1-16, 2013
1042013
Protein-protein interaction inhibitors: small molecules from screening techniques
S Fletcher, AD Hamilton
Current topics in medicinal chemistry 7 (10), 922-927, 2007
992007
BRD4 structure–activity relationships of dual PLK1 kinase/BRD4 bromodomain inhibitor BI-2536
L Chen, JL Yap, M Yoshioka, ME Lanning, RN Fountain, M Raje, ...
ACS medicinal chemistry letters 6 (7), 764-769, 2015
942015
Small molecule inhibitors of the ERK signalling pathway: towards novel anti-cancer therapeutics
JL Yap, S Worlikar, AD MacKerell Jr, P Shapiro, S Fletcher
ChemMedChem 6 (1), 38, 2011
932011
Expanding the cancer arsenal with targeted therapies: Disarmament of the antiapoptotic Bcl-2 proteins by small molecules: Miniperspective
JL Yap, L Chen, ME Lanning, S Fletcher
Journal of medicinal chemistry 60 (3), 821-838, 2017
872017
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-x L inhibitors
JL Yap, X Cao, K Vanommeslaeghe, KY Jung, C Peddaboina, PT Wilder, ...
Organic & Biomolecular Chemistry 10 (15), 2928-2933, 2012
872012
Pharmacophore identification of c-Myc inhibitor 10074-G5
JL Yap, H Wang, A Hu, J Chauhan, KY Jung, RB Gharavi, EV Prochownik, ...
Bioorganic & medicinal chemistry letters 23 (1), 370-374, 2013
812013
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ...
Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011
742011
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