Mitchell R O'Connell
Mitchell R O'Connell
Assistant Professor of Biochemistry and Biophysics, University of Rochester
Verified email at - Homepage
Cited by
Cited by
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
A East-Seletsky, MR O’Connell, SC Knight, D Burstein, JHD Cate, R Tjian, ...
Nature 538 (7624), 270-273, 2016
Programmable RNA recognition and cleavage by CRISPR/Cas9
MR O’Connell, BL Oakes, SH Sternberg, A East-Seletsky, M Kaplan, ...
Nature 516 (7530), 263-266, 2014
Programmable RNA tracking in live cells with CRISPR/Cas9
DA Nelles, MY Fang, MR O’Connell, JL Xu, SJ Markmiller, JA Doudna, ...
Cell 165 (2), 488-496, 2016
Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems
MR O'Connell
Journal of molecular biology 431 (1), 66-87, 2019
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
A East-Seletsky, MR O’Connell, D Burstein, GJ Knott, JA Doudna
Molecular Cell 66 (3), 373-383. e3, 2017
Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme
GJ Knott, A East-Seletsky, JC Cofsky, JM Holton, E Charles, ...
Nature structural & molecular biology 24 (10), 825-833, 2017
Single-stranded DNA cleavage by divergent CRISPR-Cas9 enzymes
E Ma, LB Harrington, MR O’Connell, K Zhou, JA Doudna
Molecular cell 60 (3), 398-407, 2015
RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a
A Tambe, A East-Seletsky, GJ Knott, JA Doudna, MR O’Connell
Cell reports 24 (4), 1025-1036, 2018
The structural analysis of protein–protein interactions by NMR spectroscopy
MR O'Connell, R Gamsjaeger, JP Mackay
Proteomics 9 (23), 5224-5232, 2009
Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants
YSY Hsieh, BL Wilkinson, MR O’Connell, JP Mackay, JM Matthews, ...
Organic letters 14 (7), 1910-1913, 2012
A rapid method for assessing the RNA-binding potential of a protein
K Bendak, FE Loughlin, V Cheung, MR O’Connell, M Crossley, ...
Nucleic acids research 40 (14), e105-e105, 2012
Two-timing zinc finger transcription factors liaising with RNA
J Burdach, MR O’Connell, JP Mackay, M Crossley
Trends in biochemical sciences 37 (5), 199-205, 2012
THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder
M Broly, BV Polevoda, KM Awayda, N Tong, J Lentini, T Besnard, W Deb, ...
The American Journal of Human Genetics 109 (4), 587-600, 2022
A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers
R Gamsjaeger, MR O'Connell, L Cubeddu, NE Shepherd, JA Lowry, ...
Journal of Biological Chemistry 288 (49), 35180-35191, 2013
CRISPR-Csx28 forms a Cas13b-activated membrane pore required for robust CRISPR-Cas adaptive immunity
AR VanderWal, JU Park, B Polevoda, EH Kellogg, MR O’Connell
BioRxiv, 2021.11. 02.466367, 2021
Gold Nanoparticle‐Labeled CRISPR‐Cas13a Assay for the Sensitive Solid‐State Nanopore Molecular Counting
L Liu, Z Xu, K Awayda, SJ Dollery, M Bao, J Fan, D Cormier, ...
Advanced Materials Technologies, 2101550, 2022
Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues
EJ Walker, JQ Bettinger, KA Welle, JR Hryhorenko, AMM Vargas, ...
Journal of Biological Chemistry 298 (5), 2022
Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense
AR VanderWal, JU Park, B Polevoda, JK Nicosia, AM Molina Vargas, ...
Science 380 (6643), 410-415, 2023
Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing
J Waitkus, Y Chang, L Liu, SV Puttaswamy, T Chung, AM Molina Vargas, ...
Advanced Materials Interfaces 10 (1), 2201261, 2023
Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time
BJ Davis, MR O’Connell
Molecular Cell 77 (2), 207-209, 2020
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