| Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection A East-Seletsky, MR O’Connell, SC Knight, D Burstein, JHD Cate, R Tjian, ... Nature 538 (7624), 270-273, 2016 | 1168 | 2016 |
| Programmable RNA recognition and cleavage by CRISPR/Cas9 MR O’Connell, BL Oakes, SH Sternberg, A East-Seletsky, M Kaplan, ... Nature 516 (7530), 263-266, 2014 | 779 | 2014 |
| Programmable RNA tracking in live cells with CRISPR/Cas9 DA Nelles, MY Fang, MR O’Connell, JL Xu, SJ Markmiller, JA Doudna, ... Cell 165 (2), 488-496, 2016 | 600 | 2016 |
| Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems MR O'Connell Journal of molecular biology 431 (1), 66-87, 2019 | 348 | 2019 |
| RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes A East-Seletsky, MR O’Connell, D Burstein, GJ Knott, JA Doudna Molecular Cell 66 (3), 373-383. e3, 2017 | 311 | 2017 |
| Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme GJ Knott, A East-Seletsky, JC Cofsky, JM Holton, E Charles, ... Nature structural & molecular biology 24 (10), 825-833, 2017 | 162 | 2017 |
| Single-stranded DNA cleavage by divergent CRISPR-Cas9 enzymes E Ma, LB Harrington, MR O’Connell, K Zhou, JA Doudna Molecular cell 60 (3), 398-407, 2015 | 137 | 2015 |
| RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a A Tambe, A East-Seletsky, GJ Knott, JA Doudna, MR O’Connell Cell reports 24 (4), 1025-1036, 2018 | 135 | 2018 |
| The structural analysis of protein–protein interactions by NMR spectroscopy MR O'Connell, R Gamsjaeger, JP Mackay Proteomics 9 (23), 5224-5232, 2009 | 120 | 2009 |
| Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants YSY Hsieh, BL Wilkinson, MR O’Connell, JP Mackay, JM Matthews, ... Organic letters 14 (7), 1910-1913, 2012 | 59 | 2012 |
| A rapid method for assessing the RNA-binding potential of a protein K Bendak, FE Loughlin, V Cheung, MR O’Connell, M Crossley, ... Nucleic acids research 40 (14), e105-e105, 2012 | 47 | 2012 |
| Two-timing zinc finger transcription factors liaising with RNA J Burdach, MR O’Connell, JP Mackay, M Crossley Trends in biochemical sciences 37 (5), 199-205, 2012 | 44 | 2012 |
| THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder M Broly, BV Polevoda, KM Awayda, N Tong, J Lentini, T Besnard, W Deb, ... The American Journal of Human Genetics 109 (4), 587-600, 2022 | 31 | 2022 |
| Gold Nanoparticle‐Labeled CRISPR‐Cas13a Assay for the Sensitive Solid‐State Nanopore Molecular Counting L Liu, Z Xu, K Awayda, SJ Dollery, M Bao, J Fan, D Cormier, ... Advanced Materials Technologies, 2101550, 2022 | 25 | 2022 |
| A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers R Gamsjaeger, MR O'Connell, L Cubeddu, NE Shepherd, JA Lowry, ... Journal of Biological Chemistry 288 (49), 35180-35191, 2013 | 22 | 2013 |
| Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing J Waitkus, Y Chang, L Liu, SV Puttaswamy, T Chung, AM Molina Vargas, ... Advanced Materials Interfaces 10 (1), 2201261, 2023 | 21 | 2023 |
| CRISPR-Csx28 forms a Cas13b-activated membrane pore required for robust CRISPR-Cas adaptive immunity AR VanderWal, JU Park, B Polevoda, EH Kellogg, MR O’Connell BioRxiv, 2021.11. 02.466367, 2021 | 19 | 2021 |
| Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues EJ Walker, JQ Bettinger, KA Welle, JR Hryhorenko, AMM Vargas, ... Journal of Biological Chemistry 298 (5), 2022 | 17 | 2022 |
| Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense AR VanderWal, JU Park, B Polevoda, JK Nicosia, AM Molina Vargas, ... Science 380 (6643), 410-415, 2023 | 16 | 2023 |
| New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity AM Molina Vargas, S Sinha, R Osborn, PR Arantes, A Patel, S Dewhurst, ... Nucleic Acids Research, gkad1132, 2023 | 15 | 2023 |
