| Identification and characterization of essential genes in the human genome T Wang, K Birsoy, NW Hughes, KM Krupczak, Y Post, JJ Wei, ES Lander, ... Science 350 (6264), 1096-1101, 2015 | 1786 | 2015 |
| Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras T Wang, H Yu, NW Hughes, B Liu, A Kendirli, K Klein, WW Chen, ... Cell 168 (5), 890-903. e15, 2017 | 719 | 2017 |
| dCas9-based gene editing for cleavage-free genomic knock-in of long sequences C Wang, Y Qu, JKW Cheng, NW Hughes, Q Zhang, M Wang, L Cong Nature cell biology 24 (2), 268-278, 2022 | 52 | 2022 |
| A functional taxonomy of tumor suppression in oncogenic KRAS–driven lung cancer H Cai, SK Chew, C Li, MK Tsai, L Andrejka, CW Murray, NW Hughes, ... Cancer discovery 11 (7), 1754-1773, 2021 | 48 | 2021 |
| Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects C Wang, JKW Cheng, Q Zhang, NW Hughes, Q Xia, MM Winslow, L Cong Nucleic Acids Research, 2021 | 35 | 2021 |
| Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles NW Hughes, Y Qu, J Zhang, W Tang, J Pierce, C Wang, A Agrawal, ... Molecular cell 82 (16), 3103-3118. e8, 2022 | 25 | 2022 |
| Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth R Tang, EG Shuldiner, M Kelly, CW Murray, JD Hebert, L Andrejka, ... Nature cell biology 25 (1), 159-169, 2023 | 24 | 2023 |
| The tumor suppressor BAP 1 cooperates with BRAFV 600E to promote tumor formation in cutaneous melanoma JD Webster, TH Pham, X Wu, NW Hughes, Z Li, K Totpal, HJ Lee, ... Pigment Cell & Melanoma Research 32 (2), 269-279, 2019 | 15 | 2019 |
| Iron-Promoted Construction of Indoles via Intramolecular Oxidative C–N Coupling of 2-Alkenylanilines Using Persulfate M Wang, Y Li, QA Wu, S Luo, Y Li Synthesis 51 (16), 3085-3090, 2019 | 7 | 2019 |
| CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells C Wang, Q Xia, Q Zhang, Y Qu, S Su, JKW Cheng, NW Hughes, L Cong Frontiers in Cell and Developmental Biology 9, 719705, 2022 | 5 | 2022 |
| Modeling the genomic complexity of human cancer using Cas12a mice. JD Hebert, H Xu, YJ Tang, PA Ruiz, C Detrick, J Wang, NW Hughes, ... Biorxiv: the Preprint Server for Biology, 2024 | 3 | 2024 |
| Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes YJ Tang, H Xu, NW Hughes, SH Kim, P Ruiz, EG Shuldiner, SS Lopez, ... bioRxiv, 2024.08. 19.607671, 2024 | 2 | 2024 |
| Efficient and multiplexed somatic genome editing with Cas12a mice JD Hebert, H Xu, YJ Tang, PA Ruiz, CR Detrick, J Wang, NW Hughes, ... bioRxiv, 2024.03. 07.583774, 2024 | 2 | 2024 |
| Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth R Tang, EG Shuldiner, M Kelly, CW Murray, JD Hebert, L Andrejka, ... bioRxiv, 2021.07. 08.451571, 2021 | 2 | 2021 |
| Computationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells J Marsiglia, K Vaalavirta, E Knight, M Nakamura, L Cong, NW Hughes Cell Reports Methods 4 (10), 2024 | 1 | 2024 |
| A step by step protocol for genomic knock-in of long sequences using dCas9-SSAP editor C Wang, Y Qu, JKW Cheng, NW Hughes, Q Zhang, M Wang, L Cong | 1 | 2022 |
| Compressive molecular probes for genomic editing and tracking L Cong, NW Hughes US Patent App. 18/287,619, 2024 | | 2024 |
| Abstract C056: The initiation and progression of pancreatic ductal adenocarcinoma through a p53 lens KJ Hanson, AC Minor, BM Flowers, AM Kaiser, N Hughes, H Vogel, ... Cancer Research 84 (2_Supplement), C056-C056, 2024 | | 2024 |
| Protein language model-guided engineering of an anti-CRISPR protein for precise genome editing in human cells J Marsiglia, K Vaalavirta, E Knight, M Nakamura, L Cong, NW Hughes bioRxiv, 2023.12. 13.571376, 2023 | | 2023 |
| A journey to deconvolute the multifaceted functions and context-dependency of cancer driver genes H Cai, SK Chew, C Li, CW Murray, L Andrejka, JD Hebert, MK Tsai, ... Cancer Research 82 (12_Supplement), 827-827, 2022 | | 2022 |
