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David Barford
David Barford
MRC Laboratory of Molecular Biology
Verified email at mrc-lmb.cam.ac.uk - Homepage
Title
Cited by
Cited by
Year
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan, MJ Garnett, SM Roe, S Lee, D Niculescu-Duvaz, VM Good, ...
Cell 116 (6), 855-867, 2004
32562004
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
A Salmeen, JN Andersen, MP Myers, TC Meng, JA Hinks, NK Tonks, ...
Nature 423 (6941), 769-773, 2003
11262003
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR‐mediated protein–protein interactions
AK Das, PTW Cohen, D Barford
The EMBO journal, 1998
10591998
Crystal structure of human protein tyrosine phosphatase 1B
D Barford, AJ Flint, NK Tonks
Science 263 (5152), 1397-1404, 1994
10091994
Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases
AJ Flint, T Tiganis, D Barford, NK Tonks
Proceedings of the National Academy of Sciences 94 (5), 1680-1685, 1997
9891997
The structure and mechanism of protein phosphatases: insights into catalysis and regulation
D Barford, AK Das, MP Egloff
Annual review of biophysics and biomolecular structure 27 (1), 133-164, 1998
9851998
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1
MP Egloff, DF Johnson, G Moorhead, PTW Cohen, P Cohen, D Barford
The EMBO journal, 1997
7711997
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
Z Jia, D Barford, AJ Flint, NK Tonks
Science 268 (5218), 1754-1758, 1995
7671995
Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex
JS Parker, SM Roe, D Barford
Nature 434 (7033), 663-666, 2005
6892005
Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains
D Komander, F Reyes‐Turcu, JDF Licchesi, P Odenwaelder, ...
EMBO reports 10 (5), 466-473, 2009
6882009
A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2
S George, JJ Rochford, C Wolfrum, SL Gray, S Schinner, JC Wilson, ...
Science 304 (5675), 1325-1328, 2004
6862004
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang, P Cron, VM Good, V Thompson, BA Hemmings, D Barford
Nature structural biology 9 (12), 940-944, 2002
6342002
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
MP Myers, JN Andersen, A Cheng, ML Tremblay, CM Horvath, ...
Journal of Biological Chemistry 276 (51), 47771-47774, 2001
6232001
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
MR Groves, N Hanlon, P Turowski, BA Hemmings, D Barford
Cell 96 (1), 99-110, 1999
6071999
The crystal structure of human eukaryotic release factor eRF1—mechanism of stop codon recognition and peptidyl-tRNA hydrolysis
H Song, P Mugnier, AK Das, HM Webb, DR Evans, MF Tuite, ...
Cell 100 (3), 311-321, 2000
6002000
Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate
MP Egloff, PTW Cohen, P Reinemer, D Barford
Journal of molecular biology 254 (5), 942-959, 1995
5821995
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
AK Das, NR Helps, PT Cohen, D Barford
The EMBO journal 15 (24), 6798-6809, 1996
5591996
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
J Yang, P Cron, V Thompson, VM Good, D Hess, BA Hemmings, ...
Molecular cell 9 (6), 1227-1240, 2002
5512002
Molecular mechanisms of theprotein serine/threonine phosphatases
D Barford
Trends in biochemical sciences 21 (11), 407-412, 1996
5511996
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
A Salmeen, JN Andersen, MP Myers, NK Tonks, D Barford
Molecular cell 6 (6), 1401-1412, 2000
5472000
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