| The expanding utility of continuous flow hydrogenation PJ Cossar, L Hizartzidis, MI Simone, A McCluskey, CP Gordon Organic & Biomolecular Chemistry 13 (26), 7119-7130, 2015 | 129 | 2015 |
| Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering M Wolter, D Valenti, PJ Cossar, LM Levy, S Hristeva, T Genski, ... Angewandte Chemie International Edition 59 (48), 21520-21524, 2020 | 50 | 2020 |
| Protein‐protein interactions as antibiotic targets: a medicinal chemistry perspective PJ Cossar, PJ Lewis, A McCluskey Medicinal research reviews 40 (2), 469-494, 2020 | 47 | 2020 |
| Reversible covalent imine-tethering for selective stabilization of 14-3-3 hub protein interactions PJ Cossar, M Wolter, L van Dijck, D Valenti, LM Levy, C Ottmann, ... Journal of the American Chemical Society 143 (22), 8454-8464, 2021 | 34 | 2021 |
| Expanding the utility of flow hydrogenation–a robust protocol restricting hydrodehalogenation L Hizartzidis, PJ Cossar, MJ Robertson, MI Simone, KA Young, ... RSC advances 4 (100), 56743-56748, 2014 | 20 | 2014 |
| An exploration of chemical properties required for cooperative stabilization of the 14-3-3 interaction with NF-κB—utilizing a reversible covalent tethering approach M Wolter, D Valenti, PJ Cossar, S Hristeva, LM Levy, T Genski, ... Journal of Medicinal Chemistry 64 (12), 8423-8436, 2021 | 17 | 2021 |
| Reversible dual-covalent molecular locking of the 14-3-3/ERRγ protein–protein interaction as a molecular glue drug discovery approach BA Somsen, RJC Schellekens, CJA Verhoef, MR Arkin, C Ottmann, ... Journal of the American Chemical Society 145 (12), 6741-6752, 2023 | 16 | 2023 |
| Covalent flexible peptide docking in Rosetta B Tivon, R Gabizon, BA Somsen, PJ Cossar, C Ottmann, N London Chemical Science 68 (20), 42-61, 2021 | 16 | 2021 |
| In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols PJ Cossar, JR Baker, N Cain, A McCluskey Royal Society Open Science 5 (4), 171190, 2018 | 15 | 2018 |
| Small-molecule inhibitors of the NusB–NusE protein–protein interaction with antibiotic activity PJ Cossar, MK Abdel-Hamid, C Ma, JA Sakoff, TN Trinh, CP Gordon, ... ACS omega 2 (7), 3839-3857, 2017 | 12 | 2017 |
| Identification and validation of small molecule modulators of the NusB-NusE interaction PJ Cossar, C Ma, CP Gordon, JI Ambrus, PJ Lewis, A McCluskey Bioorganic & Medicinal Chemistry Letters 27 (2), 162-167, 2017 | 12 | 2017 |
| Quinolone-1-(2 H)-ones as hedgehog signalling pathway inhibitors TN Trinh, EA McLaughlin, MK Abdel-Hamid, CP Gordon, IR Bernstein, ... Organic & Biomolecular Chemistry 14 (26), 6304-6315, 2016 | 12 | 2016 |
| Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor Γt FA Meijer, AOWM Saris, RG Doveston, GJM Oerlemans, RMJM de Vries, ... Journal of Medicinal Chemistry 64 (13), 9238-9258, 2021 | 11 | 2021 |
| Fragment-based exploration of the 14-3-3/Amot-p130 interface F Centorrino, B Andlovic, P Cossar, L Brunsveld, C Ottmann Current Research in Structural Biology 4, 21-28, 2022 | 8 | 2022 |
| Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry CJA Verhoef, DF Kay, L van Dijck, RG Doveston, L Brunsveld, AC Leney, ... Chemical Science 14 (24), 6756-6762, 2023 | 6 | 2023 |
| 3, 5-Bis (trifluoromethyl) phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety J Sun, JI Ambrus, JR Baker, CC Russell, PJ Cossar, JA Sakoff, CJ Scarlett, ... Bioorganic & Medicinal Chemistry Letters 61, 128591, 2022 | 5 | 2022 |
| Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues BA Somsen, FWB Craenmehr, WHW Liu, AA Koops, MAM Pennings, ... Chemical Science 13 (44), 13122-13131, 2022 | 5 | 2022 |
| Recent developments in the use of flow hydrogenation in the field of medicinal chemistry CC Russell, JR Baker, PJ Cossar, A McCluskey New Advances in Hydrogenation Processes-Fundamentals and Applications, 2017 | 5 | 2017 |
| Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex BA Somsen, E Sijbesma, S Leysen, K Honzejkova, EJ Visser, PJ Cossar, ... Journal of Biological Chemistry 299 (7), 2023 | 4 | 2023 |
| Amino alcohols as potential antibiotic and antifungal leads JR Baker, PJ Cossar, MAT Blaskovich, AG Elliott, J Zuegg, MA Cooper, ... Molecules 27 (7), 2050, 2022 | 4 | 2022 |
Adam McCluskeyUniversity of Newcastleכתובת אימייל מאומתת בדומיין newcastle.edu.au
