Paul A. Clemons, Ph.D.
Paul A. Clemons, Ph.D.
Institute Scientist, Computational Chemical Biology, Broad Institute
Verified email at - Homepage
Cited by
Cited by
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
J Lamb, ED Crawford, D Peck, JW Modell, IC Blat, MJ Wrobel, J Lerner, ...
science 313 (5795), 1929-1935, 2006
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
Target identification and mechanism of action in chemical biology and drug discovery
M Schenone, V Dančík, BK Wagner, PA Clemons
Nature chemical biology 9 (4), 232-240, 2013
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ...
Nature 547 (7664), 453-457, 2017
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules
A Basu, NE Bodycombe, JH Cheah, EV Price, K Liu, GI Schaefer, ...
Cell 154 (5), 1151-1161, 2013
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
MG Rees, B Seashore-Ludlow, JH Cheah, DJ Adams, EV Price, S Gill, ...
Nature chemical biology 12 (2), 109-116, 2016
Harnessing connectivity in a large-scale small-molecule sensitivity dataset
B Seashore-Ludlow, MG Rees, JH Cheah, M Cokol, EV Price, ME Coletti, ...
Cancer discovery 5 (11), 1210-1223, 2015
ChemBank : a small-molecule screening and cheminformatics resource database
KP Seiler, GA George, MP Happ, NE Bodycombe, HA Carrinski, S Norton, ...
Nucleic acids research 36 (suppl_1), D351-D359, 2007
Data-analysis strategies for image-based cell profiling
JC Caicedo, S Cooper, F Heigwer, S Warchal, P Qiu, C Molnar, ...
Nature methods 14 (9), 849-863, 2017
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
PA Clemons, NE Bodycombe, HA Carrinski, JA Wilson, AF Shamji, ...
Proceedings of the National Academy of Sciences 107 (44), 18787-18792, 2010
Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia
DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ...
Cell 167 (1), 171-186. e15, 2016
Route to three-dimensional fragments using diversity-oriented synthesis
AW Hung, A Ramek, Y Wang, T Kaya, JA Wilson, PA Clemons, DW Young
Proceedings of the National Academy of Sciences 108 (17), 6799-6804, 2011
Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
L Jerby-Arnon, N Pfetzer, YY Waldman, L McGarry, D James, E Shanks, ...
Cell 158 (5), 1199-1209, 2014
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ...
Nature 538 (7625), 344-349, 2016
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
A Gutierrez, L Pan, RWJ Groen, F Baleydier, A Kentsis, J Marineau, ...
The Journal of clinical investigation 124 (2), 644-655, 2014
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Y Zou, MJ Palte, AA Deik, H Li, JK Eaton, W Wang, YY Tseng, R Deasy, ...
Nature communications 10 (1), 1-13, 2019
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
MJ Wawer, K Li, SM Gustafsdottir, V Ljosa, NE Bodycombe, MA Marton, ...
Proceedings of the National Academy of Sciences 111 (30), 10911-10916, 2014
Multiplex cytological profiling assay to measure diverse cellular states
SM Gustafsdottir, V Ljosa, KL Sokolnicki, J Anthony Wilson, D Walpita, ...
PloS one 8 (12), e80999, 2013
A one-bead, one-stock solution approach to chemical genetics: part 2
PA Clemons, AN Koehler, BK Wagner, TG Sprigings, DR Spring, RW King, ...
Chemistry & biology 8 (12), 1183-1195, 2001
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