Aviad Tsherniak
Aviad Tsherniak
Broad Institute of Harvard and MIT
Verified email at broadinstitute.org - Homepage
Title
Cited by
Cited by
Year
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
YJ Cho, A Tsherniak, P Tamayo, S Santagata, A Ligon, H Greulich, ...
Journal of Clinical Oncology 29 (11), 1424, 2011
6002011
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
5262012
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
4862017
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ...
The Journal of clinical investigation 123 (1), 2012
4322012
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779-1784, 2017
3902017
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ...
Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011
3752011
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ...
Cancer discovery 6 (8), 914-929, 2016
3542016
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ...
Scientific data 1 (1), 1-12, 2014
2872014
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
2422019
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325-330, 2018
2372018
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ...
Nature medicine 21 (12), 1491-1496, 2015
2092015
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ...
Science 351 (6278), 1214-1218, 2016
1822016
Cancer vulnerabilities unveiled by genomic loss
D Nijhawan, TI Zack, Y Ren, MR Strickland, R Lamothe, SE Schumacher, ...
Cell 150 (4), 842-854, 2012
1802012
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens
DD Shao, A Tsherniak, S Gopal, BA Weir, P Tamayo, N Stransky, ...
Genome research 23 (4), 665-678, 2013
1182013
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer
L Li, C Shen, E Nakamura, K Ando, S Signoretti, R Beroukhim, GS Cowley, ...
Cancer cell 24 (6), 738-750, 2013
1082013
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
C Yu, AM Mannan, GM Yvone, KN Ross, YL Zhang, MA Marton, BR Taylor, ...
Nature biotechnology 34 (4), 419-423, 2016
942016
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Nature communications 9 (1), 1-13, 2018
782018
Mutational processes shape the landscape of TP53 mutations in human cancer
AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ...
Nature genetics 50 (10), 1381-1387, 2018
782018
The landscape of cancer cell line metabolism
H Li, S Ning, M Ghandi, GV Kryukov, S Gopal, A Deik, A Souza, K Pierce, ...
Nature medicine 25 (5), 850, 2019
742019
Characterizing genomic alterations in cancer by complementary functional associations
JW Kim, OB Botvinnik, O Abudayyeh, C Birger, J Rosenbluh, Y Shrestha, ...
Nature biotechnology 34 (5), 539-546, 2016
612016
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Articles 1–20