| A humanized system for pharmacologic control of gene expression VM Rivera, T Clackson, S Natesan, R Pollock, JF Amara, T Keenan, ... Nature medicine 2 (9), 1028-1032, 1996 | 693 | 1996 |
| Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity T Clackson, WU Yang, LW Rozamus, M Hatada, JF Amara, CT Rollins, ... Proceedings of the National Academy of Sciences 95 (18), 10437-10442, 1998 | 638 | 1998 |
| Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum VM Rivera, X Wang, S Wardwell, NL Courage, A Volchuk, T Keenan, ... Science 287 (5454), 826-830, 2000 | 401 | 2000 |
| Expression and isolation of antimicrobial small molecules from soil DNA libraries IA MacNeil, CL Tiong, C Minor, PR August, TH Grossman, KA Loiacono, ... Journal of molecular microbiology and biotechnology 3 (2), 301-308, 2001 | 333 | 2001 |
| Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12 DA Holt, JI Luengo, DS Yamashita, HJ Oh, AL Konialian, HK Yen, ... Journal of the American Chemical Society 115 (22), 9925-9938, 2002 | 330 | 2002 |
| A versatile synthetic dimerizer for the regulation of protein–protein interactions JF Amara, T Clackson, VM Rivera, T Guo, T Keenan, S Natesan, ... Proceedings of the national academy of sciences 94 (20), 10618-10623, 1997 | 261 | 1997 |
| A ligand-reversible dimerization system for controlling protein–protein interactions CT Rollins, VM Rivera, DN Woolfson, T Keenan, M Hatada, SE Adams, ... Proceedings of the National Academy of Sciences 97 (13), 7096-7101, 2000 | 208 | 2000 |
| Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum PR August, TH Grossman, C Minor, MP Draper, IA MacNeil, ... Journal of molecular microbiology and biotechnology 2 (4), 513-519, 2000 | 198 | 2000 |
| Inhibition of steroid 5. alpha.-reductase by unsaturated 3-carboxy steroids DA Holt, MA Levy, HJ Oh, JM Erb, JI Heaslip, M Brandt, HY Lan-Hargest, ... Journal of medicinal chemistry 33 (3), 943-950, 1990 | 154 | 1990 |
| Inhibitors of steroid 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne BW Metcalf, MA Levy, DA Holt Trends in Pharmacological Sciences 10 (12), 491-495, 1989 | 136 | 1989 |
| Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors DA Holt, AL Konialian-Beck, HJ Oh, HK Yen, LW Rozamus, AJ Krog, ... Bioorganic & Medicinal Chemistry Letters 4 (2), 315-320, 1994 | 119 | 1994 |
| Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface JI Luengo, DS Yamashita, D Dunnington, AK Beck, LW Rozamus, HK Yen, ... Chemistry & Biology 2 (7), 471-481, 1995 | 112 | 1995 |
| Palladium-catalyzed phosphorylation of alkenyl triflates DA Holt, JM Erb Tetrahedron letters 30 (40), 5393-5396, 1989 | 103 | 1989 |
| Investigating protein− ligand interactions with a mutant FKBP possessing a designed specificity pocket W Yang, LW Rozamus, S Narula, CT Rollins, R Yuan, LJ Andrade, ... Journal of medicinal chemistry 43 (6), 1135-1142, 2000 | 100 | 2000 |
| Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins T Keenan, DR Yaeger, NL Courage, CT Rollins, ME Pavone, VM Rivera, ... Bioorganic & medicinal chemistry 6 (8), 1309-1335, 1998 | 95 | 1998 |
| Cloning, expression and functional characterization of type 1 and type 2 steroid 5α-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymes MA Levy, M Brandt, KM Sheedy, DA Holt, JI Heaslip, JJ Trill, PJ Ryan, ... The Journal of Steroid Biochemistry and Molecular Biology 52 (4), 307-319, 1995 | 95 | 1995 |
| Steroidal A ring aryl carboxylic acids: a new class of steroid 5. alpha.-reductase inhibitors DA Holt, MA Levy, DL Ladd, HJ Oh, JM Erb, JI Heaslip, M Brandt, ... Journal of medicinal chemistry 33 (3), 937-942, 1990 | 95 | 1990 |
| Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2 MA Levy, M Brandt, KM Sheedy, JT Dinh, DA Holt, LM Garrison, ... The Journal of Steroid Biochemistry and Molecular Biology 48 (2-3), 197-206, 1994 | 88 | 1994 |
| Studies on the chemistry of rapamycin: novel transformations under Lewis-acid catalysis JI Luengo, AL Konialian, DA Holt Tetrahedron letters 34 (6), 991-994, 1993 | 88 | 1993 |
| Discovery of GSK2193874: an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 M Cheung, W Bao, DJ Behm, CA Brooks, MJ Bury, SE Dowdell, HS Eidam, ... ACS medicinal chemistry letters 8 (5), 549-554, 2017 | 87 | 2017 |
