| RNAi modulation of placental sFLT1 for the treatment of preeclampsia AA Turanov, A Lo, MR Hassler, A Makris, A Ashar-Patel, JF Alterman, ... Nature biotechnology 36 (12), 1164-1173, 2018 | 159 | 2018 |
| A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system JF Alterman, BMDC Godinho, MR Hassler, CM Ferguson, D Echeverria, ... Nature biotechnology 37 (8), 884-894, 2019 | 152 | 2019 |
| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 148 | 2018 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic acids research 47 (3), 1070-1081, 2019 | 112 | 2019 |
| 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo RA Haraszti, L Roux, AH Coles, AA Turanov, JF Alterman, D Echeverria, ... Nucleic acids research 45 (13), 7581-7592, 2017 | 99 | 2017 |
| Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles RA Haraszti, R Miller, MC Didiot, A Biscans, JF Alterman, MR Hassler, ... Molecular Therapy 26 (8), 1973-1982, 2018 | 83 | 2018 |
| Pharmacokinetic profiling of conjugated therapeutic oligonucleotides: a high-throughput method based upon serial blood microsampling coupled to peptide nucleic acid … BMDC Godinho, JW Gilbert, RA Haraszti, AH Coles, A Biscans, L Roux, ... nucleic acid therapeutics 27 (6), 323-334, 2017 | 44 | 2017 |
| Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ... Molecular Therapy 26 (6), 1520-1528, 2018 | 40 | 2018 |
| How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy A Pasquier, S Alais, L Roux, MI Thoulouze, K Alvarez, C Journo, ... Frontiers in microbiology 9, 278, 2018 | 39 | 2018 |
| Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study L Roux, S Priet, N Payrot, C Weck, M Fournier, F Zoulim, J Balzarini, ... European Journal of Medicinal Chemistry 63, 869-881, 2013 | 36 | 2013 |
| Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity WF Lim, M Forouhan, TC Roberts, J Dabney, R Ellerington, AA Speciale, ... Science Advances 7 (34), eabi6896, 2021 | 22 | 2021 |
| Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: effect of the α-phosphorus configuration on HIV-1 RT activity S Priet, L Roux, M Saez-Ayala, F Ferron, B Canard, K Alvarez Antiviral Research 117, 122-131, 2015 | 13 | 2015 |
| Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication K Barral, C Weck, N Payrot, L Roux, C Durafour, F Zoulim, J Neyts, ... European journal of medicinal chemistry 46 (9), 4281-4288, 2011 | 11 | 2011 |
| Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain M Saez-Ayala, EL Yekwa, C Mondielli, L Roux, S Hernández, F Bailly, ... Antiviral Research 162, 79-89, 2019 | 8 | 2019 |
| Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity K Yamada, S Hildebrand, SM Davis, R Miller, F Conroy, E Sapp, J Caiazzi, ... Nucleic Acids Research 49 (21), 12069-12088, 2021 | 7 | 2021 |
| Synthesis of modified oligonucleotides with increased stability A Khvorova, LMRJ Roux, K Yamada US Patent App. 17/213,852, 2022 | 6 | 2022 |
| Modified oligonucleotides with increased stability A Khvorova, LMRJ Roux, K Yamada US Patent 11,820,985, 2023 | 5 | 2023 |
| Synthetic oligonucleotides having regions of block and cluster modifications A Khvorova, LMRJ Roux, K Yamada US Patent App. 17/331,146, 2021 | 2 | 2021 |
| (R)-9-[2-(Hydroxyphosphinylmethoxy) propyl] adenine as the precursor molecule for antivirals L Roux, B Canard, K Alvarez Tetrahedron letters 55 (30), 4168-4171, 2014 | 2 | 2014 |
| Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition R Agnes, R Haraszti, ML Miller, M DiFiglia, N Aronin | | 2019 |
