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Reggy Ekkebus
Reggy Ekkebus
Verified email at nki.nl
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Year
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
TET Mevissen, MK Hospenthal, PP Geurink, PR Elliott, M Akutsu, ...
Cell 154 (1), 169-184, 2013
5682013
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases
R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, PP Geurink, ...
Journal of the American Chemical Society, 2013
3392013
Chemical Synthesis of Ubiquitin, Ubiquitin‐Based Probes, and Diubiquitin
F El Oualid, R Merkx, R Ekkebus, DS Hameed, JJ Smit, A de Jong, ...
Angewandte Chemie International Edition 49 (52), 10149-10153, 2010
3262010
BAP1/ASXL1 recruitment and activation for H2A deubiquitination
DD Sahtoe, WJ Van Dijk, R Ekkebus, H Ovaa, TK Sixma
Nature communications 7 (1), 10292, 2016
1842016
Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease
M Békés, R Ekkebus, H Ovaa, TT Huang, CD Lima
Molecular cell 62 (4), 572-585, 2016
1372016
Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures
M Eggink, M Wijtmans, R Ekkebus, H Lingeman, IJP Esch, J Kool, ...
Analytical chemistry 80 (23), 9042-9051, 2008
1242008
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G
DD Sahtoe, WJ van Dijk, F El Oualid, R Ekkebus, H Ovaa, TK Sixma
Molecular cell 57 (5), 887-900, 2015
1162015
Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets
D Flierman, R Ekkebus, PP Geurink, TET Mevissen, MK Hospenthal, ...
Cell chemical biology 23 (4), 472-482, 2016
1072016
Altered peptide ligands revisited: Vaccine design through chemically modified HLA-A2–restricted T cell epitopes
R Hoppes, R Oostvogels, JJ Luimstra, K Wals, M Toebes, L Bies, ...
The Journal of Immunology 193 (10), 4803-4813, 2014
572014
Catching a DUB in the act: novel ubiquitin-based active site directed probes
R Ekkebus, D Flierman, PP Geurink, H Ovaa
Current opinion in chemical biology 23, 63-70, 2014
532014
Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism
T van Welsem, T Korthout, R Ekkebus, D Morais, TM Molenaar, ...
Nucleic acids research 46 (21), 11251-11261, 2018
342018
Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity
RQ Kim, PP Geurink, MPC Mulder, A Fish, R Ekkebus, F El Oualid, ...
Nature communications 10 (1), 231, 2019
292019
Technologies for MHC class I immunoproteomics
R Hoppes, R Ekkebus, TNM Schumacher, H Ovaa
Journal of proteomics 73 (10), 1945-1953, 2010
222010
es, AJ Heck, D. Komander and H. Ovaa
R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, PP Geurink, ...
J. Am. Chem. Soc 135, 2867-2870, 2013
72013
P. d.; Kool, J.; Niessen, WMA; Irth, H. Development of a Selective ESI-MS Derivatization Reagent: Synthesis and Optimization for the Analysis of Aldehydes in Biological Mixtures
M Eggink, M Wijtmans, R Ekkebus, H Lingeman, IJ Esch
Anal. Chem 80, 9042-9051, 2008
52008
Cysteine protease capturing agents
H Ovaa, R Ekkebus, SI Van Kasteren, A De Jong, PP Geurink
US Patent App. 14/412,990, 2015
32015
HLA-A2
M Schumacher, T Mutis, B Rodenko, H Ovaa, E Emmelot, RM Spaapen, ...
2014
Non-hydrolyzable protein conjugates, methods and compositions related thereto
H Ovaa, A Shanmugham, R Ekkebus, F El Oualid, R Merkx
2011
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases–Supplementary Materials
R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, AJ Geurink, ...
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