| Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction JB Siegel, A Zanghellini, HM Lovick, G Kiss, AR Lambert, JL St. Clair, ... Science 329 (5989), 309-313, 2010 | 1152 | 2010 |
| Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 696 | 2020 |
| Computational protein design enables a novel one-carbon assimilation pathway JB Siegel, AL Smith, S Poust, AJ Wargacki, A Bar-Even, C Louw, ... Proceedings of the National Academy of Sciences 112 (12), 3704-3709, 2015 | 399 | 2015 |
| Increased Diels-Alderase activity through backbone remodeling guided by Foldit players CB Eiben, JB Siegel, JB Bale, S Cooper, F Khatib, BW Shen, F Players, ... Nature biotechnology 30 (2), 190-192, 2012 | 386 | 2012 |
| Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase N Preiswerk, T Beck, JD Schulz, P Milovník, C Mayer, JB Siegel, D Baker, ... Proceedings of the National Academy of Sciences 111 (22), 8013-8018, 2014 | 164 | 2014 |
| Computational design of an α-gliadin peptidase SR Gordon, EJ Stanley, S Wolf, A Toland, SJ Wu, D Hadidi, JH Mills, ... Journal of the American Chemical Society 134 (50), 20513-20520, 2012 | 151 | 2012 |
| Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta R Kleffner, J Flatten, A Leaver-Fay, D Baker, JB Siegel, F Khatib, ... Bioinformatics 33 (17), 2765-2767, 2017 | 123 | 2017 |
| Engineering of Kuma030: a gliadin peptidase that rapidly degrades immunogenic gliadin peptides in gastric conditions C Wolf, JB Siegel, C Tinberg, A Camarca, C Gianfrani, S Paski, R Guan, ... Journal of the American Chemical Society 137 (40), 13106-13113, 2015 | 122 | 2015 |
| Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis WB Black, L Zhang, WS Mak, S Maxel, Y Cui, E King, B Fong, ... Nature chemical biology 16 (1), 87-94, 2020 | 98 | 2020 |
| Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway WS Mak, S Tran, R Marcheschi, S Bertolani, J Thompson, D Baker, ... Nature communications 6 (1), 10005, 2015 | 96 | 2015 |
| Expanding the product profile of a microbial alkane biosynthetic pathway M Harger, L Zheng, A Moon, C Ager, JH An, C Choe, YL Lai, B Mo, ... ACS synthetic biology 2 (1), 59-62, 2013 | 91 | 2013 |
| Computational enzyme design: transitioning from catalytic proteins to enzymes WS Mak, JB Siegel Current opinion in structural biology 27, 87-94, 2014 | 89 | 2014 |
| Evaluating protein engineering thermostability prediction tools using an independently generated dataset P Huang, SKS Chu, HN Frizzo, MP Connolly, RW Caster, JB Siegel ACS omega 5 (12), 6487-6493, 2020 | 68 | 2020 |
| Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4 E Seo, J Woo, E Park, SJ Bertolani, JB Siegel, D Choi, SP Dinesh-Kumar Autophagy 12 (11), 2054-2068, 2016 | 62 | 2016 |
| Biofuel production Y Kashiyama, Y Yoshikuni, D Baker, JB Siegel US Patent App. 12/245,540, 2009 | 57 | 2009 |
| Kinetic characterization of 100 glycoside hydrolase mutants enables the discovery of structural features correlated with kinetic constants DA Carlin, RW Caster, X Wang, SA Betzenderfer, CX Chen, VM Duong, ... PLoS One 11 (1), e0147596, 2016 | 54 | 2016 |
| Mechanistic analysis of an engineered enzyme that catalyzes the formose reaction S Poust, J Piety, A Bar‐Even, C Louw, D Baker, JD Keasling, JB Siegel ChemBioChem 16 (13), 1950-1954, 2015 | 54 | 2015 |
| Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue PR Denish, JA Fenger, R Powers, GT Sigurdson, L Grisanti, ... Science advances 7 (15), eabe7871, 2021 | 51 | 2021 |
| Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction TE O'Brien, SJ Bertolani, DJ Tantillo, JB Siegel Chemical science 7 (7), 4009-4015, 2016 | 48 | 2016 |
| Preliminary techno-economic assessment of animal cell-based meat D Risner, F Li, JS Fell, SA Pace, JB Siegel, I Tagkopoulos, ES Spang Foods 10 (1), 3, 2020 | 44 | 2020 |
David BakerUniversity of WashingtonVerified email at uw.edu
