Matthew Welsch
Matthew Welsch
Kleo Pharmaceuticals
Verified email at kleopharmaceuticals.com
Title
Cited by
Cited by
Year
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
18342014
Privileged scaffolds for library design and drug discovery
ME Welsch, SA Snyder, BR Stockwell
Current opinion in chemical biology 14 (3), 347-361, 2010
12392010
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
SJ Dixon, DN Patel, M Welsch, R Skouta, ED Lee, M Hayano, AG Thomas, ...
elife 3, e02523, 2014
6692014
Multivalent small-molecule pan-RAS inhibitors
ME Welsch, A Kaplan, JM Chambers, ME Stokes, PH Bos, A Zask, ...
Cell 168 (5), 878-889. e29, 2017
1652017
Modulatory profiling identifies mechanisms of small molecule-induced cell death
AJ Wolpaw, K Shimada, R Skouta, ME Welsch, UD Akavia, D Pe'er, ...
Proceedings of the National Academy of Sciences 108 (39), E771-E780, 2011
1122011
Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design
ME Welsch, J Zhou, Y Gao, Y Yan, G Porter, G Agnihotri, Y Li, H Lu, ...
ACS medicinal chemistry letters 7 (12), 1124-1129, 2016
162016
Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
BR Stockwell, M Welsch, WS Yang
US Patent 9,695,133, 2017
142017
Small molecule that reverses dexamethasone resistance in T-cell acute lymphoblastic leukemia (T-ALL)
AM Cantley, M Welsch, A Ambesi-Impiombato, M Sanchez-Martin, ...
ACS medicinal chemistry letters 5 (7), 754-759, 2014
132014
A first-in-class ex vivo combination between cytokine-induced memory like (CIML) NK cells and a CD38 targeting antibody recruiting molecule (ARM) as a novel approach to target …
L Rastelli, M Mohsin, AM Rossi, E Alvarez Sotomayor, L Iben, A Vaill, ...
Journal of Clinical Oncology 38 (15_suppl), 8523-8523, 2020
12020
Compositions and methods for treating infections
SB Thomas, AT Hopper, M Welsch
US Patent App. 17/016,702, 2020
2020
Universal abt compounds and uses thereof
DA Spiegel, ME Welsch
US Patent App. 16/634,032, 2020
2020
KPMW135, a Biosuperior CD3 Bispecific Version of Rituximab Created By a Novel Chemical Conjugation Technology Demonstrates Increased Anti-Tumor Activity By Adding T Cell …
C Vidal, M Cukan, A Vaill, A Bunin, AM Rossi, L Iben, D Trinh, K McGrath, ...
Blood 136, 9-10, 2020
2020
635 A novel site-directed chemical conjugation technology confers antitumor activity via native Fc receptor to plasma immunoglobulin by attaching tumor binders
C Vidal, M Cukan, R Varma, L Iben, T Berbasova, A Vaill, A Bunin, ...
Journal for ImmunoTherapy of Cancer 8 (Suppl 3), 2020
2020
Antibody-recruiting molecules for the treatment of cancer
D Spiegel, HM Loughran, JC Pelletier, AB Reitz, ME Welsch
US Patent 10,780,084, 2020
2020
Compositions and methods for treating infections
SB Thomas, AT Hopper, M Welsch
US Patent 10,774,073, 2020
2020
A Novel Class of Bifunctional Immunotherapeutic That Exploit a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cells Expressing CD38 Demonstrates …
AM Rossi, A Bunin, L Iben, M Welsch, T Berbasova, C Riillo, M Rossi, ...
Blood, The Journal of the American Society of Hematology 134 (Supplement_1 …, 2019
2019
A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate …
A Bunin, K McGrath, AM Rossi, M Welsch, C Vidal, D Trinh, D Spiegel, ...
Blood, The Journal of the American Society of Hematology 134 (Supplement_1 …, 2019
2019
Multivalent RAS binding compounds
BR Stockwell, M Welsch
US Patent 9,926,293, 2018
2018
Computational tools and interdisciplinary ingenuity for accelerating the development of new medicine
ME Welsch, SG Stergiopoulos
2016
Computational design, synthesis, and biological evaluation of small molecule anti-cancer therapeutics
ME Welsch
Columbia University, 2015
2015
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